Literature DB >> 172470

Cyclic appearance of defective interfering particles of herpes simplex virus and the concomitant accumulation of early polypeptide VP175.

B K Murray, N Biswal, J B Bookout, R E Lanford, R J Courtney, J L Melnick.   

Abstract

Serial passage of undiluted herpes simplex virus types 1 and 2 resulted in cyclic production of infectious and defective virions. Defective virus production was characterized by the appearance of a new species of viral DNA with a higher bouyant density in CsCl than standard viral DNA. Measurement of the infectivity titer and DNA synthesis revealed that the defective particles interfered with the replication of standard virions and stimulated the overproduction of a large molecular weight (175,000 daltons) polypeptide.

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Year:  1975        PMID： 172470     DOI： 10.1159/000149894

Source DB:  PubMed          Journal:  Intervirology        ISSN： 0300-5526            Impact factor:   1.763


  16 in total

1.  Structure and origin of defective genomes contained in serially passaged herpes simplex virus type 1 (Justin).

Authors:  H Locker; N Frenkel
Journal:  J Virol       Date:  1979-03       Impact factor: 5.103

2.  Origin of two different classes of defective HSV-1 Angelotti DNA.

Authors:  H C Kaerner; I B Maichle; A Ott; C H Schröder
Journal:  Nucleic Acids Res       Date:  1979-04       Impact factor: 16.971

3.  DNA-binding proteins induced by herpes simplex virus type 2 in HEp-2 cells.

Authors:  D J Purifoy; K L Powell
Journal:  J Virol       Date:  1976-08       Impact factor: 5.103

4.  Effects of temperature and antibody on the cyclid growth of vesicular stomatitis virus.

Authors:  P Sinarachatanant; A S Huang
Journal:  J Virol       Date:  1977-01       Impact factor: 5.103

5.  Herpes simplex virus type 1 Angelotti and a defective viral genotype: analysis of genome structures and genetic relatedness by DNA-DNA reassociation kinetics.

Authors:  A Ott; B Föhring; H C Kaerner
Journal:  J Virol       Date:  1979-02       Impact factor: 5.103

6.  Amplification of a short nucleotide sequence in the repeat units of defective herpes simplex virus type 1 Angelotti DNA.

Authors:  H C Kaerner; A Ott-Hartmann; R Schatten; C H Schröder; C P Gray
Journal:  J Virol       Date:  1981-07       Impact factor: 5.103

7.  Structure and expression of class II defective herpes simplex virus genomes encoding infected cell polypeptide number 8.

Authors:  H Locker; N Frenkel; I Halliburton
Journal:  J Virol       Date:  1982-08       Impact factor: 5.103

8.  Class I defective herpes simplex virus DNA as a molecular cloning vehicle in eucaryotic cells.

Authors:  J W Barnett; D A Eppstein; H W Chan
Journal:  J Virol       Date:  1983-11       Impact factor: 5.103

9.  Ultrastructural characterization of an early, nonstructural polypeptide of herpes simplex virus type 1.

Authors:  G A Cabral; R J Courtney; P A Schaffer; F Marciano-Cabral
Journal:  J Virol       Date:  1980-03       Impact factor: 5.103

10.  Protection from oral herpes simplex virus infection by a nucleic acid-free virus vaccine.

Authors:  E N Kitces; P S Morahan; J G Tew; B K Murray
Journal:  Infect Immun       Date:  1977-06       Impact factor: 3.441
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