| Literature DB >> 18541199 |
Tomer Mark1, Jessica Stern, Jessica R Furst, David Jayabalan, Faiza Zafar, April LaRow, Roger N Pearse, John Harpel, Tsiporah Shore, Michael W Schuster, John P Leonard, Paul J Christos, Morton Coleman, Ruben Niesvizky.
Abstract
A total of 28 treatment-naïve patients with stage II or III multiple myeloma (MM) were treated with the combination of clarithromycin, lenalidomide, and dexamethasone (BiRD). Stem cells were collected following granulocyte-colony stimulating factor (G-CSF) or cyclophosphamide (Cy) plus G-CSF mobilization at maximum response. Sufficient stem cells for 2 autologous stem cell transplants were collected from all patients mobilized with Cy plus G-CSF, versus 33% mobilized with G-CSF alone (P < .0001). The duration of prior lenalidomide therapy did not correlate with success of stem cell harvests (P = .91). In conclusion, Cy can be added to G-CSF for stem cell mobilization to successfully overcome the suppressive effect of prior treatment with lenalidomide.Entities:
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Year: 2008 PMID： 18541199 PMCID： PMC3626097 DOI： 10.1016/j.bbmt.2008.04.008
Source DB: PubMed Journal: Biol Blood Marrow Transplant ISSN： 1083-8791 Impact factor: 5.742