Literature DB >> 18539520

Genomic RNAi screening in Drosophila S2 cells: what have we learned about host-pathogen interactions?

Sara Cherry1.   

Abstract

The détente between pathogen and host has been of keen interest to researchers in spite of being exceedingly difficult to probe. Recently, new RNA interference (RNAi) technologies, in particular in Drosophila tissue culture cells, have made it possible to interrogate the genetics of host organisms rapidly, with nearly complete genomic coverage and high fidelity. Therefore, it is not surprising that the applications of RNAi to the study of host-pathogen interactions were among the first to be published and have already revealed many new insights into the hosts' role in infection. This review will highlight the application of RNAi screening to pathogen-host interactions in Drosophila cells and will reveal some of the lessons learned from this approach.

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Year:  2008        PMID： 18539520      PMCID： PMC2525573          DOI： 10.1016/j.mib.2008.05.007

Source DB:  PubMed          Journal:  Curr Opin Microbiol        ISSN： 1369-5274            Impact factor:   7.934


  59 in total

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Journal:  Immunol Rev       Date:  2000-02       Impact factor: 12.988

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Authors:  M Elrod-Erickson; S Mishra; D Schneider
Journal:  Curr Biol       Date:  2000-06-29       Impact factor: 10.834

3.  Drosophila scavenger receptor CI is a pattern recognition receptor for bacteria.

Authors:  M Rämet; A Pearson; P Manfruelli; X Li; H Koziel; V Göbel; E Chung; M Krieger; R A Ezekowitz
Journal:  Immunity       Date:  2001-12       Impact factor: 31.745

4.  Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli.

Authors:  Mika Rämet; Pascal Manfruelli; Alan Pearson; Bernard Mathey-Prevot; R Alan B Ezekowitz
Journal:  Nature       Date:  2002-03-24       Impact factor: 49.962

5.  A brief history of Drosophila's contributions to genome research.

Authors:  G M Rubin; E B Lewis
Journal:  Science       Date:  2000-03-24       Impact factor: 47.728

Review 6.  Developmental patterning genes and their conserved functions: from model organisms to humans.

Authors:  A Veraksa; M Del Campo; W McGinnis
Journal:  Mol Genet Metab       Date:  2000-02       Impact factor: 4.797

7.  ESCRT factors restrict mycobacterial growth.

Authors:  Jennifer A Philips; Maura C Porto; Hui Wang; Eric J Rubin; Norbert Perrimon
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-19       Impact factor: 11.205

Review 8.  Drosophila melanogaster as a model system for drug discovery and pathway screening.

Authors:  Sanjay Tickoo; Steven Russell
Journal:  Curr Opin Pharmacol       Date:  2002-10       Impact factor: 5.547

9.  RNA interference screen identifies Abl kinase and PDGFR signaling in Chlamydia trachomatis entry.

Authors:  Cherilyn A Elwell; Alhaji Ceesay; Jung Hwa Kim; Daniel Kalman; Joanne N Engel
Journal:  PLoS Pathog       Date:  2008-03-07       Impact factor: 6.823

10.  RNAi screen reveals an Abl kinase-dependent host cell pathway involved in Pseudomonas aeruginosa internalization.

Authors:  Julia F Pielage; Kimberly R Powell; Daniel Kalman; Joanne N Engel
Journal:  PLoS Pathog       Date:  2008-03-21       Impact factor: 6.823
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  29 in total

Review 1.  New insights into the biological effects of anthrax toxins: linking cellular to organismal responses.

Authors:  Annabel Guichard; Victor Nizet; Ethan Bier
Journal:  Microbes Infect       Date:  2011-09-08       Impact factor: 2.700

Review 2.  Systems biology in immunology: a computational modeling perspective.

Authors:  Ronald N Germain; Martin Meier-Schellersheim; Aleksandra Nita-Lazar; Iain D C Fraser
Journal:  Annu Rev Immunol       Date:  2011       Impact factor: 28.527

Review 3.  RNAi screening: new approaches, understandings, and organisms.

Authors:  Stephanie E Mohr; Norbert Perrimon
Journal:  Wiley Interdiscip Rev RNA       Date:  2011-09-22       Impact factor: 9.957

4.  Drosophila as a model for antiviral immunity.

Authors:  Jing-Huan Wang; Susanna Valanne; Mika Rämet
Journal:  World J Biol Chem       Date:  2010-05-26

Review 5.  Viruses and antiviral immunity in Drosophila.

Authors:  Jie Xu; Sara Cherry
Journal:  Dev Comp Immunol       Date:  2013-05-13       Impact factor: 3.636

6.  Molecular bases of proliferation of Francisella tularensis in arthropod vectors.

Authors:  Rexford Asare; Christine Akimana; Snake Jones; Yousef Abu Kwaik
Journal:  Environ Microbiol       Date:  2010-05-07       Impact factor: 5.491

Review 7.  RNAi screening comes of age: improved techniques and complementary approaches.

Authors:  Stephanie E Mohr; Jennifer A Smith; Caroline E Shamu; Ralph A Neumüller; Norbert Perrimon
Journal:  Nat Rev Mol Cell Biol       Date:  2014-09       Impact factor: 94.444

8.  Expression in aneuploid Drosophila S2 cells.

Authors:  Yu Zhang; John H Malone; Sara K Powell; Vipul Periwal; Eric Spana; David M Macalpine; Brian Oliver
Journal:  PLoS Biol       Date:  2010-02-23       Impact factor: 8.029

9.  RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening.

Authors:  Saša Stefanić; Jan Dvořák; Martin Horn; Simon Braschi; Daniel Sojka; Debbie S Ruelas; Brian Suzuki; Kee-Chong Lim; Stephanie D Hopkins; James H McKerrow; Conor R Caffrey
Journal:  PLoS Negl Trop Dis       Date:  2010-10-19

Review 10.  RNAi screening in Drosophila cells and in vivo.

Authors:  Stephanie E Mohr
Journal:  Methods       Date:  2014-02-24       Impact factor: 3.608
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