| Literature DB >> 18524948 |
Hira Lal Goel1, Jing Li, Sophia Kogan, Lucia R Languino.
Abstract
Integrins, which are transmembrane receptors for extracellular matrix proteins, play a key role in cell survival, proliferation, migration, gene expression, and activation of growth factor receptors. Their functions and expression are deregulated in several types of cancer, including prostate cancer. In this article, we review the role of integrins in prostate cancer progression and their potential as therapeutic targets.Entities:
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Year: 2008 PMID: 18524948 PMCID: PMC2668544 DOI: 10.1677/ERC-08-0019
Source DB: PubMed Journal: Endocr Relat Cancer ISSN: 1351-0088 Impact factor: 5.678