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Literature DB >> 185240

Chemotherapeutic compounds and Acanthamoebae from eye infections.

Abstract

The amoebicidal and amoebistatic action in vitro of 24 compounds was tested on two strains of Acanthamoeba, A. polyphaga and A. castellanii, isolated from eye infections in this country. For comparison, the Ryan strain of A. castellanii and Naegleria gruberi L-1 were also examined. Nine compounds showed sufficient activity to merit further consideration, ie, acriflavine, proflavine, hydroxystilbamidine isethionate, paromomycin, miconazole, amphoterin, neomycin, polymyxin, and the last two combined in Neosporin.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1976 PMID： 185240 PMCID： PMC476134 DOI： 10.1136/jcp.29.7.648

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

9 in total

1. HARTMANELLA CASTELLANI (ACANTHAMOEBA SP): PRELIMINARY REPORT ON EXPERIMENTAL CHEMOTHERAPY.

Authors: C G CULBERTSON; D H HOLMES; W M OVERTON
Journal: Am J Clin Pathol Date: 1965-04 Impact factor: 2.493

2. Effect of clotrimazole on Naegleria fowleri.

Authors: A Jamieson
Journal: J Clin Pathol Date: 1975-06 Impact factor: 3.411

Review 3. Primary amoebic meningo-encephalitis. An appraisal of present knowledge.

Authors: R F Carter
Journal: Trans R Soc Trop Med Hyg Date: 1972 Impact factor: 2.184

4. Ryan virus: a possible new human pathogen.

Authors: M S Pereira; H B Marsden; G Corbitt; J O Tobin
Journal: Br Med J Date: 1966-01-15

5. Study of a small amoeba from mammalian cell cultures infected with 'Ryan virus'.

Authors: D C Warhurst; J A Armstrong
Journal: J Gen Microbiol Date: 1968-02

6. Amoebic infection of the eye.

Authors: J Naginton; P G Watson; T J Playfair; J McGill; B R Jones; A D Steele
Journal: Lancet Date: 1974-12-28 Impact factor: 79.321

7. Primary amoebic meningoencephalitis in Britain.

Authors: J Apley; S K Clarke; A P Roome; S A Sandry; G Saygi; B Silk; D C Warhurst
Journal: Br Med J Date: 1970-03-07

8. Sensitivity of Hartmannella (Acanthamoeba) to 5-fluorocytosine, hydroxystilbamidine, and other substances.

Authors: D P Casemore
Journal: J Clin Pathol Date: 1970-11 Impact factor: 3.411

9. Sensitivity to amphotericin B of a Naegleria sp. isolated from a case of primary amoebic meningoencephalitis.

Authors: R F Carter
Journal: J Clin Pathol Date: 1969-07 Impact factor: 3.411

9 in total

17 in total

1. Differentiation of Acanthamoeba strains from infected corneas and the environment by using restriction endonuclease digestion of whole-cell DNA.

Authors: S Kilvington; J R Beeching; D G White
Journal: J Clin Microbiol Date: 1991-02 Impact factor: 5.948

Chemotherapeutic compounds and Acanthamoebae from eye infections.

1. HARTMANELLA CASTELLANI (ACANTHAMOEBA SP): PRELIMINARY REPORT ON EXPERIMENTAL CHEMOTHERAPY.

2. Effect of clotrimazole on Naegleria fowleri.

Review 3. Primary amoebic meningo-encephalitis. An appraisal of present knowledge.

4. Ryan virus: a possible new human pathogen.

5. Study of a small amoeba from mammalian cell cultures infected with 'Ryan virus'.

6. Amoebic infection of the eye.

7. Primary amoebic meningoencephalitis in Britain.

8. Sensitivity of Hartmannella (Acanthamoeba) to 5-fluorocytosine, hydroxystilbamidine, and other substances.

9. Sensitivity to amphotericin B of a Naegleria sp. isolated from a case of primary amoebic meningoencephalitis.

1. Differentiation of Acanthamoeba strains from infected corneas and the environment by using restriction endonuclease digestion of whole-cell DNA.

Review 2. The Development of Drugs against Acanthamoeba Infections.

3. Differentiation of Naegleria fowleri from Acanthamoeba species by using monoclonal antibodies and flow cytometry.

4. Susceptibility of Acanthamoeba castellanii to contact lens disinfecting solutions.

5. Acanthamoeba keratitis successfully treated medically.

6. Phenothiazine compounds inhibit in vitro growth of pathogenic free-living amoebae.

7. Acanthamoebic keratitis diagnosed by paracentesis and biopsy and treated with propamidine.

8. Laboratory investigation of Acanthamoeba keratitis.

9. A quantitative method to evaluate neutralizer toxicity against Acanthamoeba castellanii.

10. Acanthamoeba keratitis. A clinicopathological case report.