| Literature DB >> 185228 |
Abstract
During aggregation the larger Dictyostelium species use cAMP as a chemoattractant and possibly also as a transmitter. In passage from cell to cell, cAMP levels are modulated by diffusion and by enzyme hydrolysis. It appears that the important cAMP-hydrolysing enzyme is a phosphodiesterase bound to the cell membrane, the main roles of which are (1) very fast hydrolysis of cAMP and (2) steepening of spatial cAMP gradients. An extracellular phosphodiesterase has no function, so far as can be conjectured from present data.Entities:
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Year: 1976 PMID： 185228 DOI： 10.1242/jcs.22.1.49
Source DB: PubMed Journal: J Cell Sci ISSN： 0021-9533 Impact factor: 5.285