Literature DB >> 18521069

p53: The Janus of autophagy?

Beth Levine, John Abrams.   

Abstract

The autophagy pathway functions in adaptation to nutrient stress and tumour suppression. The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology.

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Year:  2008        PMID： 18521069      PMCID： PMC2739720          DOI： 10.1038/ncb0608-637

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  14 in total

Review 1.  p53 and metabolism: Inside the TIGAR.

Authors:  Douglas R Green; Jerry E Chipuk
Journal:  Cell       Date:  2006-07-14       Impact factor: 41.582

Review 2.  Self-eating and self-killing: crosstalk between autophagy and apoptosis.

Authors:  M Chiara Maiuri; Einat Zalckvar; Adi Kimchi; Guido Kroemer
Journal:  Nat Rev Mol Cell Biol       Date:  2007-09       Impact factor: 94.444

3.  The coordinate regulation of the p53 and mTOR pathways in cells.

Authors:  Zhaohui Feng; Haiyan Zhang; Arnold J Levine; Shengkan Jin
Journal:  Proc Natl Acad Sci U S A       Date:  2005-05-31       Impact factor: 11.205

4.  p53 directs focused genomic responses in Drosophila.

Authors:  F Akdemir; A Christich; N Sogame; J Chapo; J M Abrams
Journal:  Oncogene       Date:  2007-02-19       Impact factor: 9.867

5.  Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma.

Authors:  Ravi K Amaravadi; Duonan Yu; Julian J Lum; Thi Bui; Maria A Christophorou; Gerard I Evan; Andrei Thomas-Tikhonenko; Craig B Thompson
Journal:  J Clin Invest       Date:  2007-01-18       Impact factor: 14.808

6.  Regulation of autophagy by cytoplasmic p53.

Authors:  Ezgi Tasdemir; M Chiara Maiuri; Lorenzo Galluzzi; Ilio Vitale; Mojgan Djavaheri-Mergny; Marcello D'Amelio; Alfredo Criollo; Eugenia Morselli; Changlian Zhu; Francis Harper; Ulf Nannmark; Chrysanthi Samara; Paolo Pinton; José Miguel Vicencio; Rosa Carnuccio; Ute M Moll; Frank Madeo; Patrizia Paterlini-Brechot; Rosario Rizzuto; Gyorgy Szabadkai; Gérard Pierron; Klas Blomgren; Nektarios Tavernarakis; Patrice Codogno; Francesco Cecconi; Guido Kroemer
Journal:  Nat Cell Biol       Date:  2008-05-04       Impact factor: 28.824

7.  Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis.

Authors:  Kirsteen H Maclean; Frank C Dorsey; John L Cleveland; Michael B Kastan
Journal:  J Clin Invest       Date:  2008-01       Impact factor: 14.808

8.  p53-Dependent and p53-independent activation of autophagy by ARF.

Authors:  Wassim M Abida; Wei Gu
Journal:  Cancer Res       Date:  2008-01-15       Impact factor: 12.701

9.  DRAM, a p53-induced modulator of autophagy, is critical for apoptosis.

Authors:  Diane Crighton; Simon Wilkinson; Jim O'Prey; Nelofer Syed; Paul Smith; Paul R Harrison; Milena Gasco; Ornella Garrone; Tim Crook; Kevin M Ryan
Journal:  Cell       Date:  2006-07-14       Impact factor: 41.582

Review 10.  Autophagy in the pathogenesis of disease.

Authors:  Beth Levine; Guido Kroemer
Journal:  Cell       Date:  2008-01-11       Impact factor: 41.582
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  107 in total

1.  PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy.

Authors:  Samisubbu R Naidu; Alexander J Lakhter; Elliot J Androphy
Journal:  Cell Cycle       Date:  2012-07-15       Impact factor: 4.534

2.  Cell death in the pathogenesis and progression of heart failure.

Authors:  José Marín-García
Journal:  Heart Fail Rev       Date:  2016-03       Impact factor: 4.214

3.  Proceedings of the 2013 National Toxicology Program Satellite Symposium.

Authors:  Susan A Elmore; Michael C Boyle; Molly H Boyle; Michelle C Cora; Torrie A Crabbs; Connie A Cummings; Margarita M Gruebbel; Crystal L Johnson; David E Malarkey; Elizabeth F McInnes; Thomas Nolte; Cynthia C Shackelford; Jerrold M Ward
Journal:  Toxicol Pathol       Date:  2013-12-13       Impact factor: 1.902

Review 4.  DNA damage and autophagy.

Authors:  Humberto Rodriguez-Rocha; Aracely Garcia-Garcia; Mihalis I Panayiotidis; Rodrigo Franco
Journal:  Mutat Res       Date:  2011-03-17       Impact factor: 2.433

5.  Learning to get along despite struggling to get by.

Authors:  Elizabeth A Ostrowski; Gad Shaulsky
Journal:  Genome Biol       Date:  2009-05-26       Impact factor: 13.583

6.  The roles of mitochondria in radiation-induced autophagic cell death in cervical cancer cells.

Authors:  Zongyan Chen; Benli Wang; Feifei Yu; Qiao Chen; Yuxi Tian; Shumei Ma; Xiaodong Liu
Journal:  Tumour Biol       Date:  2015-10-21

7.  Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy.

Authors:  Tom Verfaillie; Maria Salazar; Guillermo Velasco; Patrizia Agostinis
Journal:  Int J Cell Biol       Date:  2010-01-17

8.  ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy.

Authors:  Kathryn G Eby; Jennifer M Rosenbluth; Deborah J Mays; Clayton B Marshall; Christopher E Barton; Seema Sinha; Kimberly N Johnson; Luojia Tang; Jennifer A Pietenpol
Journal:  Mol Cancer       Date:  2010-04-29       Impact factor: 27.401

9.  Another "Janus paradox" of p53: induction of cell senescence versus quiescence.

Authors:  Zbigniew Darzynkiewicz
Journal:  Aging (Albany NY)       Date:  2010-06       Impact factor: 5.682

10.  Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy.

Authors:  Khong Bee Kang; Congju Zhu; Sook Kwin Yong; Qiuhan Gao; Meng Cheong Wong
Journal:  Mol Cancer       Date:  2009-08-25       Impact factor: 27.401
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