Literature DB >> 18191218

Autophagy in the pathogenesis of disease.

Beth Levine1, Guido Kroemer.   

Abstract

Autophagy is a lysosomal degradation pathway that is essential for survival, differentiation, development, and homeostasis. Autophagy principally serves an adaptive role to protect organisms against diverse pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. However, in certain experimental disease settings, the self-cannibalistic or, paradoxically, even the prosurvival functions of autophagy may be deleterious. This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases.

Entities:  

Mesh：

Year:  2008        PMID： 18191218      PMCID： PMC2696814          DOI： 10.1016/j.cell.2007.12.018

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  101 in total

Review 1.  Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications.

Authors:  Andrea Williams; Luca Jahreiss; Sovan Sarkar; Shinji Saiki; Fiona M Menzies; Brinda Ravikumar; David C Rubinsztein
Journal:  Curr Top Dev Biol       Date:  2006       Impact factor: 4.897

2.  Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity.

Authors:  Takahiro Kamimoto; Shisako Shoji; Tunda Hidvegi; Noboru Mizushima; Kyohei Umebayashi; David H Perlmutter; Tamotsu Yoshimori
Journal:  J Biol Chem       Date:  2005-12-19       Impact factor: 5.157

3.  Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes.

Authors:  Anne Hamacher-Brady; Nathan R Brady; Roberta A Gottlieb
Journal:  J Biol Chem       Date:  2006-08-01       Impact factor: 5.157

Review 4.  Protein turnover via autophagy: implications for metabolism.

Authors:  Noboru Mizushima; Daniel J Klionsky
Journal:  Annu Rev Nutr       Date:  2007       Impact factor: 11.848

Review 5.  Autophagy: from phenomenology to molecular understanding in less than a decade.

Authors:  Daniel J Klionsky
Journal:  Nat Rev Mol Cell Biol       Date:  2007-11       Impact factor: 94.444

Review 6.  The role of autophagy in alpha-1-antitrypsin deficiency: a specific cellular response in genetic diseases associated with aggregation-prone proteins.

Authors:  David H Perlmutter
Journal:  Autophagy       Date:  2006-10-05       Impact factor: 16.016

Review 7.  Role of autophagy in cancer: management of metabolic stress.

Authors:  Shengkan Jin; Eileen White
Journal:  Autophagy       Date:  2007-01-03       Impact factor: 16.016

8.  Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease).

Authors:  I Nishino; J Fu; K Tanji; T Yamada; S Shimojo; T Koori; M Mora; J E Riggs; S J Oh; Y Koga; C M Sue; A Yamamoto; N Murakami; S Shanske; E Byrne; E Bonilla; I Nonaka; S DiMauro; M Hirano
Journal:  Nature       Date:  2000-08-24       Impact factor: 49.962

9.  Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1.

Authors:  M Chiara Maiuri; Gaëtane Le Toumelin; Alfredo Criollo; Jean-Christophe Rain; Fabien Gautier; Philippe Juin; Ezgi Tasdemir; Gérard Pierron; Kostoula Troulinaki; Nektarios Tavernarakis; John A Hickman; Olivier Geneste; Guido Kroemer
Journal:  EMBO J       Date:  2007-04-19       Impact factor: 11.598

10.  Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice.

Authors:  Masaaki Komatsu; Satoshi Waguri; Takashi Ueno; Junichi Iwata; Shigeo Murata; Isei Tanida; Junji Ezaki; Noboru Mizushima; Yoshinori Ohsumi; Yasuo Uchiyama; Eiki Kominami; Keiji Tanaka; Tomoki Chiba
Journal:  J Cell Biol       Date:  2005-05-02       Impact factor: 10.539
View more
  2000 in total

1.  Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses.

Authors:  Fabien P Blanchet; Arnaud Moris; Damjan S Nikolic; Martin Lehmann; Sylvain Cardinaud; Romaine Stalder; Eduardo Garcia; Christina Dinkins; Florence Leuba; Li Wu; Olivier Schwartz; Vojo Deretic; Vincent Piguet
Journal:  Immunity       Date:  2010-05-06       Impact factor: 31.745

2.  Identification of an autophagy defect in smokers' alveolar macrophages.

Authors:  Martha M Monick; Linda S Powers; Katherine Walters; Nina Lovan; Michael Zhang; Alicia Gerke; Sif Hansdottir; Gary W Hunninghake
Journal:  J Immunol       Date:  2010-10-04       Impact factor: 5.422

3.  Nuclear translocation of anamorsin during drug-induced dopaminergic neurodegeneration in culture and in rat brain.

Authors:  Kyung-Ah Park; Nuri Yun; Dong-Ik Shin; So Yoen Choi; Hyun Kim; Won-Ki Kim; Yuzuru Kanakura; Hirohiko Shibayama; Young J Oh
Journal:  J Neural Transm (Vienna)       Date:  2010-10-06       Impact factor: 3.575

Review 4.  Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease.

Authors:  Stefan W Ryter; Seon-Jin Lee; Augustine Mk Choi
Journal:  Expert Rev Respir Med       Date:  2010-10       Impact factor: 3.772

5.  HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells.

Authors:  J I-Ju Leu; Julia Pimkina; Pooja Pandey; Maureen E Murphy; Donna L George
Journal:  Mol Cancer Res       Date:  2011-06-02       Impact factor: 5.852

6.  Mutations in FYCO1 cause autosomal-recessive congenital cataracts.

Authors:  Jianjun Chen; Zhiwei Ma; Xiaodong Jiao; Robert Fariss; Wanda Lee Kantorow; Marc Kantorow; Eran Pras; Moshe Frydman; Elon Pras; Sheikh Riazuddin; S Amer Riazuddin; J Fielding Hejtmancik
Journal:  Am J Hum Genet       Date:  2011-06-10       Impact factor: 11.025

7.  The insufficiency of ATG4A in macroautophagy.

Authors:  Nathan Nguyen; Taryn J Olivas; Antonio Mires; Jiaxin Jin; Shenliang Yu; Lin Luan; Shanta Nag; Karlina J Kauffman; Thomas J Melia
Journal:  J Biol Chem       Date:  2020-07-30       Impact factor: 5.157

8.  Reactive Oxygen Species-Mediated c-Jun NH2-Terminal Kinase Activation Contributes to Hepatitis B Virus X Protein-Induced Autophagy via Regulation of the Beclin-1/Bcl-2 Interaction.

Authors:  Linmao Zhong; Wangqin Shu; Wangbin Dai; Bo Gao; Sidong Xiong
Journal:  J Virol       Date:  2017-07-12       Impact factor: 5.103

Review 9.  How do I kill thee? Let me count the ways: p53 regulates PARP-1 dependent necrosis.

Authors:  Rana Elkholi; Jerry E Chipuk
Journal:  Bioessays       Date:  2013-10-24       Impact factor: 4.345

10.  Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes.

Authors:  Peter Kijun Kim; Dale Warren Hailey; Robert Thomas Mullen; Jennifer Lippincott-Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-12       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.