Literature DB >> 1852011

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.

R H Purdy1, A L Morrow, P H Moore, S M Paul.   

Abstract

A 3 alpha-hydroxy A-ring-reduced metabolite of progesterone, 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone), and one of deoxycorticosterone (DOC), 3 alpha,21-dihydroxy-5 alpha-pregnan-20- one (allotetrahydroDOC), are among the most potent known ligands of gamma-aminobutyric acid (GABA) receptors designated GABAA in the central nervous system. With specific radioimmunoassays, rapid (less than 5 min) and robust (4- to 20-fold) increases of allopregnanolone and allotetrahydroDOC were detected in the brain (cerebral cortex and hypothalamus) and in plasma of rats after exposure to ambient temperature swin stress. Neither steroid was detectable in the plasma of adrenalectomized rats either before or after swim stress. However, allopregnanolone, but not allotetrahydroDOC, was still present in the cerebral cortex (greater than 3 ng/g) after adrenalectomy. These data demonstrate the presence of allopregnanolone and allotetrahydroDOC in brain and show that acute stress results in a rapid increase of these neuroactive steroids to levels known to modulate GABAA receptor function.

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Year:  1991        PMID: 1852011      PMCID: PMC51699          DOI: 10.1073/pnas.88.10.4553

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  39 in total

1.  Physiological variations in the ovarian production of 5alpha-pregnane derivatives with sedative properties in the rat.

Authors:  M Holzbauer
Journal:  J Steroid Biochem       Date:  1975-09       Impact factor: 4.292

2.  Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency.

Authors:  A L Morrow; P D Suzdak; S M Paul
Journal:  Eur J Pharmacol       Date:  1987-10-27       Impact factor: 4.432

3.  Potentiation of gamma-aminobutyric-acid-activated chloride conductance by a steroid anaesthetic in cultured rat spinal neurones.

Authors:  J L Barker; N L Harrison; G D Lange; D G Owen
Journal:  J Physiol       Date:  1987-05       Impact factor: 5.182

4.  Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex.

Authors:  N L Harrison; M D Majewska; J W Harrington; J L Barker
Journal:  J Pharmacol Exp Ther       Date:  1987-04       Impact factor: 4.030

Review 5.  Neurosteroids: a new brain function?

Authors:  E E Baulieu; P Robel
Journal:  J Steroid Biochem Mol Biol       Date:  1990-11-20       Impact factor: 4.292

6.  Radioimmunoassay of 3 alpha-hydroxy-5 alpha-pregnan-20-one in rat and human plasma.

Authors:  R H Purdy; P H Moore; P N Rao; N Hagino; T Yamaguchi; P Schmidt; D R Rubinow; A L Morrow; S M Paul
Journal:  Steroids       Date:  1990-07       Impact factor: 2.668

7.  Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action.

Authors:  K W Gee; M B Bolger; R E Brinton; H Coirini; B S McEwen
Journal:  J Pharmacol Exp Ther       Date:  1988-08       Impact factor: 4.030

8.  In vivo secretion of 3 alpha-hydroxy-5 alpha-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat.

Authors:  M Holzbauer; M K Birmingham; A F De Nicola; J T Oliver
Journal:  J Steroid Biochem       Date:  1985-01       Impact factor: 4.292

9.  Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids.

Authors:  J A Peters; E F Kirkness; H Callachan; J J Lambert; A J Turner
Journal:  Br J Pharmacol       Date:  1988-08       Impact factor: 8.739

10.  Anxiolytic activity of an endogenous adrenal steroid.

Authors:  J N Crawley; J R Glowa; M D Majewska; S M Paul
Journal:  Brain Res       Date:  1986-11-29       Impact factor: 3.252

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  240 in total

1.  Neurosteroid modulation of GABA IPSCs is phosphorylation dependent.

Authors:  A Fáncsik; D M Linn; J G Tasker
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2.  Pivagabine decreases stress-related hormone secretion in women with hypothalamic amenorrhea.

Authors:  A D Genazzani; M Stomati; C Bersi; S Luisi; M Fedalti; M Santuz; G Esposito; F Petraglia; A R Genazzani
Journal:  J Endocrinol Invest       Date:  2000-09       Impact factor: 4.256

Review 3.  Neurogenic pain and steroid synthesis in the spinal cord.

Authors:  Christine Patte-Mensah; Cherkaouia Kibaly; Domitille Boudard; Véronique Schaeffer; Aurélie Béglé; Simona Saredi; Laurence Meyer; Ayikoe G Mensah-Nyagan
Journal:  J Mol Neurosci       Date:  2006       Impact factor: 3.444

4.  Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors.

Authors:  Brandon M Stell; Stephen G Brickley; C Y Tang; Mark Farrant; Istvan Mody
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-17       Impact factor: 11.205

Review 5.  Neuroactive steroids and anxiety disorders.

Authors:  Jean-Michel Le Mellédo; Glen B Baker
Journal:  J Psychiatry Neurosci       Date:  2002-05       Impact factor: 6.186

6.  Oxytocin regulates neurosteroid modulation of GABA(A) receptors in supraoptic nucleus around parturition.

Authors:  Jan-Jurjen Koksma; Ronald E van Kesteren; Thomas W Rosahl; Ruud Zwart; August B Smit; Hartmut Lüddens; Arjen B Brussaard
Journal:  J Neurosci       Date:  2003-02-01       Impact factor: 6.167

Review 7.  NMDA receptors and metaplasticity: mechanisms and possible roles in neuropsychiatric disorders.

Authors:  Charles F Zorumski; Yukitoshi Izumi
Journal:  Neurosci Biobehav Rev       Date:  2012-01-02       Impact factor: 8.989

8.  Simultaneous quantification of GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in human and rat serum.

Authors:  Patrizia Porcu; Todd K O'Buckley; Sarah E Alward; Christine E Marx; Lawrence J Shampine; Susan S Girdler; A Leslie Morrow
Journal:  Steroids       Date:  2009-01-13       Impact factor: 2.668

Review 9.  Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies.

Authors:  Patrizia Porcu; A Leslie Morrow
Journal:  Psychopharmacology (Berl)       Date:  2014-04-26       Impact factor: 4.530

10.  Role of pregnane xenobiotic receptor in the midbrain ventral tegmental area for estradiol- and 3α,5α-THP-facilitated lordosis of female rats.

Authors:  C A Frye; C J Koonce; A A Walf
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