Literature DB >> 2879610

Anxiolytic activity of an endogenous adrenal steroid.

J N Crawley, J R Glowa, M D Majewska, S M Paul.   

Abstract

The A-ring reduced metabolite of deoxycorticosterone, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone (THDOC) was recently shown to act at the gamma-aminobutyric acid receptor-chloride ion channel complex in rat brain. The behavioral profile of THDOC was investigated using two animal models of anxiety, the two-chambered mouse exploration test and the lick suppression conflict test. THDOC showed anxiolytic activity in both animal models, with an anxiolytic dose range, 5-15 mg/kg i.p., separable from the sedative dose range, above 20-30 mg/kg i.p.

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Year:  1986        PMID： 2879610     DOI： 10.1016/0006-8993(86)91500-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  63 in total

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Journal:  Pain Med       Date:  2010-08-23       Impact factor: 3.750

Review 2.  Identification and characterization of a pregnane steroid recognition site that is functionally coupled to an expressed GABAA receptor.

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Authors:  Chunsheng Wang; Christine E Marx; A Leslie Morrow; Wilkie A Wilson; Scott D Moore
Journal:  Neurosci Lett       Date:  2007-01-05       Impact factor: 3.046

4.  Cortical 3 alpha-hydroxy-5 alpha-pregnan-20-one levels after acute administration of Delta 9-tetrahydrocannabinol, cocaine and morphine.

Authors:  A Chistina Grobin; Margaret J VanDoren; Linda J Porrino; A Leslie Morrow
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Review 5.  Neurosteroids: endogenous role in the human brain and therapeutic potentials.

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Journal:  Prog Brain Res       Date:  2010       Impact factor: 2.453

Review 6.  Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection.

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Review 7.  Neurosteroids and GABAergic signaling in health and disease.

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Journal:  Biomol Concepts       Date:  2013-02

8.  Modulation of pair bonding in female prairie voles (Microtus ochrogaster) by corticosterone.

Authors:  A C DeVries; M B DeVries; S Taymans; C S Carter
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

9.  Comparative behavioral characterization of the neuroactive steroids 3 alpha-OH,5 alpha-pregnan-20-one and 3 alpha-OH,5 beta-pregnan-20-one in rodents.

Authors:  S Wieland; J D Belluzzi; L Stein; N C Lan
Journal:  Psychopharmacology (Berl)       Date:  1995-03       Impact factor: 4.530

10.  alpha1beta2delta, a silent GABAA receptor: recruitment by tracazolate and neurosteroids.

Authors:  N Zheleznova; A Sedelnikova; D S Weiss
Journal:  Br J Pharmacol       Date:  2008-01-21       Impact factor: 8.739
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