OBJECTIVE: To investigate the performance of low-dose, dual-source computed tomography (DSCT) coronary angiography in the step-and-shoot (SAS) mode for the diagnosis of significant coronary artery stenoses in comparison with conventional coronary angiography (CCA). DESIGN, SETTING AND PATIENTS: Prospective, single-centre study conducted in a referral centre enrolling 120 patients (71 men, mean (SD) age 68 (9) years, mean (SD) body mass index 26.2 (3.2) kg/m2). All study participants underwent DSCT in the SAS mode and CCA within 14 days. Twenty-seven patients were given intravenous beta blockers for heart rate reduction before CT. Patients were excluded if a target heart rate <or=70 bpm could not be achieved by beta blockers or when the patients were in non-sinus rhythm. Two blinded readers independently evaluated coronary artery segments for assessability and for the presence of significant (>50%) stenoses. Sensitivity, specificity, negative (NPV) and positive predictive values (PPV) were determined, with CCA being the standard of reference. Radiation dose values were calculated. RESULTS: DSCT coronary angiography in the SAS mode was successfully performed in all 120 patients. Mean (SD) heart rate during scanning was 59 (6) bpm (range 44-69). 1773/1803 coronary segments (98%) were depicted with a diagnostic image quality in 109/120 patients (91%). The overall patient-based sensitivity, specificity, PPV and NPV for the diagnosis of significant stenoses were 100%, 93%, 94% and 100%, respectively. The mean (SD) effective dose of the CT protocol was 2.5 (0.8) mSv (range 1.2-4.4). CONCLUSIONS: DSCT coronary angiography in the SAS mode allows, in selected patients with a regular heart rate, the accurate diagnosis of significant coronary stenoses at a low radiation dose.
OBJECTIVE: To investigate the performance of low-dose, dual-source computed tomography (DSCT) coronary angiography in the step-and-shoot (SAS) mode for the diagnosis of significant coronary artery stenoses in comparison with conventional coronary angiography (CCA). DESIGN, SETTING AND PATIENTS: Prospective, single-centre study conducted in a referral centre enrolling 120 patients (71 men, mean (SD) age 68 (9) years, mean (SD) body mass index 26.2 (3.2) kg/m2). All study participants underwent DSCT in the SAS mode and CCA within 14 days. Twenty-seven patients were given intravenous beta blockers for heart rate reduction before CT. Patients were excluded if a target heart rate <or=70 bpm could not be achieved by beta blockers or when the patients were in non-sinus rhythm. Two blinded readers independently evaluated coronary artery segments for assessability and for the presence of significant (>50%) stenoses. Sensitivity, specificity, negative (NPV) and positive predictive values (PPV) were determined, with CCA being the standard of reference. Radiation dose values were calculated. RESULTS: DSCT coronary angiography in the SAS mode was successfully performed in all 120 patients. Mean (SD) heart rate during scanning was 59 (6) bpm (range 44-69). 1773/1803 coronary segments (98%) were depicted with a diagnostic image quality in 109/120 patients (91%). The overall patient-based sensitivity, specificity, PPV and NPV for the diagnosis of significant stenoses were 100%, 93%, 94% and 100%, respectively. The mean (SD) effective dose of the CT protocol was 2.5 (0.8) mSv (range 1.2-4.4). CONCLUSIONS: DSCT coronary angiography in the SAS mode allows, in selected patients with a regular heart rate, the accurate diagnosis of significant coronary stenoses at a low radiation dose.
Authors: E Maffei; C Martini; S De Crescenzo; T Arcadi; A Clemente; E Capuano; A Rossi; R Malagò; N Mollet; A Weustink; C Tedeschi; L La Grutta; S Seitun; A Igoren Guaricci; F Cademartiri Journal: Radiol Med Date: 2010-06-23 Impact factor: 3.469
Authors: Lifeng Yu; Xin Liu; Shuai Leng; James M Kofler; Juan C Ramirez-Giraldo; Mingliang Qu; Jodie Christner; Joel G Fletcher; Cynthia H McCollough Journal: Imaging Med Date: 2009-10
Authors: Peter B Noël; Thomas Köhler; Alexander A Fingerle; Kevin M Brown; Stanislav Zabic; Daniela Münzel; Bernhard Haller; Thomas Baum; Martin Henninger; Reinhard Meier; Ernst J Rummeny; Martin Dobritz Journal: J Med Imaging (Bellingham) Date: 2014-10-09
Authors: Lars Husmann; Bernhard A Herzog; Nina Burkhard; Fuminari Tatsugami; Ines Valenta; Oliver Gaemperli; Christophe A Wyss; Ulf Landmesser; Philipp A Kaufmann Journal: Eur Radiol Date: 2009-02-24 Impact factor: 5.315