Literature DB >> 18510949

MicroRNA switches in Trypanosoma brucei.

Bibekanand Mallick1, Zhumur Ghosh, Jayprokas Chakrabarti.   

Abstract

Trypanosoma brucei develops chronic infection in mammalian hosts due to a sophisticated strategy of antigenic variation of variant surface glycoprotein (VSG) coat to escape antibody-mediated lysis. MicroRNAs are a class of non-coding RNAs with presumed post-transcriptional regulatory activity. Homology based informatic approach is used to identify the microRNA (miRNA) genes of T. brucei and their target mRNAs. Our observation reveals a set of microRNAs targeting mRNAs corresponding to VSGs. Further, a number of miRNA hairpins have been found in clusters of multiple identical copies. The target proteins, 20S proteosome, GM6 and GRESAG 4.2 corresponding to these clustered miRNAs play essential role in trypanosomiasis. These snippets can act as genetic switches modulating host-parasite interaction and provide useful clue toward treatment of trypanosomiasis.

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Year:  2008        PMID： 18510949     DOI： 10.1016/j.bbrc.2008.05.084

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  18 in total

Review 1.  MicroRNAs of parasites: current status and future perspectives.

Authors:  Quan Liu; Wenbin Tuo; Hongwei Gao; Xing-Quan Zhu
Journal:  Parasitol Res       Date:  2010-06-08       Impact factor: 2.289

Review 2.  The emerging world of small silencing RNAs in protozoan parasites.

Authors:  Vanessa D Atayde; Christian Tschudi; Elisabetta Ullu
Journal:  Trends Parasitol       Date:  2011-04-15

Review 3.  New perspectives on the diversification of the RNA interference system: insights from comparative genomics and small RNA sequencing.

Authors:  Alexander Maxwell Burroughs; Yoshinari Ando; L Aravind
Journal:  Wiley Interdiscip Rev RNA       Date:  2013-12-05       Impact factor: 9.957

4.  Pseudogene-derived small interference RNAs regulate gene expression in African Trypanosoma brucei.

Authors:  Yan-Zi Wen; Ling-Ling Zheng; Jian-You Liao; Ming-Hui Wang; Ying Wei; Xue-Min Guo; Liang-Hu Qu; Francisco J Ayala; Zhao-Rong Lun
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-29       Impact factor: 11.205

Review 5.  RNA interference in protozoan parasites: achievements and challenges.

Authors:  Nikolay G Kolev; Christian Tschudi; Elisabetta Ullu
Journal:  Eukaryot Cell       Date:  2011-07-15

Review 6.  Untranslated regions of mRNA and their role in regulation of gene expression in protozoan parasites.

Authors:  Shilpa J Rao; Sangeeta Chatterjee; Jayantapal K Pal
Journal:  J Biosci       Date:  2017-03       Impact factor: 1.826

Review 7.  Trans-kingdom small RNA transfer during host-pathogen interactions: The case of P. falciparum and erythrocytes.

Authors:  Katelyn A Walzer; Jen-Tsan Chi
Journal:  RNA Biol       Date:  2017-02-17       Impact factor: 4.652

8.  The Evolutionary Loss of RNAi Key Determinants in Kinetoplastids as a Multiple Sporadic Phenomenon.

Authors:  Andrey V Matveyev; João M P Alves; Myrna G Serrano; Vladimir Lee; Ana M Lara; William A Barton; André G Costa-Martins; Stephen M Beverley; Erney P Camargo; Marta M G Teixeira; Gregory A Buck
Journal:  J Mol Evol       Date:  2017-02-16       Impact factor: 2.395

Review 9.  Circulatory microRNAs: promising non-invasive prognostic and diagnostic biomarkers for parasitic infections.

Authors:  Hossein Ghalehnoei; Abouzar Bagheri; Mahdi Fakhar; Mohammad Amir Mishan
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2019-10-15       Impact factor: 3.267

Review 10.  microRNAs in parasites and parasite infection.

Authors:  Yadong Zheng; Xuepeng Cai; Janette E Bradley
Journal:  RNA Biol       Date:  2013-02-07       Impact factor: 4.652
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