| Literature DB >> 1850716 |
K Ishiwata1, T Ido, A A Mejia, M Ichihashi, Y Mishima.
Abstract
The 18F-labeling of 4-borono-D-L-phenylalanine (BPA), a potential target compound for cancer treatment with boron neutron capture therapy, is described. By direct fluorination of BPA with [18F]AcOF or [18F]F2 followed by HPLC separation, 4-borono-2-[18F]fluoro-D,L-phenylalanine was prepared with radiochemical yields of 25-35% and with a radiochemical purity of over 99%. The tissue distribution study showed that the compound has potential as a tracer for pancreas imaging with positron emission tomography. Radiation dosimetry is also described.Entities:
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Year: 1991 PMID： 1850716 DOI： 10.1016/0883-2889(91)90133-l
Source DB: PubMed Journal: Int J Rad Appl Instrum A ISSN： 0883-2889