| Literature DB >> 18503202 |
Masato Iwatsuki1, Ryuji Uchida, Hitomi Yoshijima, Hideaki Ui, Kazuro Shiomi, Yong-Pil Kim, Tomoyasu Hirose, Toshiaki Sunazuka, Akio Abe, Hiroshi Tomoda, Satoshi Omura.
Abstract
The structures of guadinomines, new inhibitors of a bacterial Type III secretion system produced by Streptomyces sp. K01-0509, were elucidated by spectroscopic studies including various NMR experiments. Guadinomines A, B, C(1), C(2) and D consist of a carbamoylated cyclic guanidinyl moiety, an alkyl chain moiety and an L-Ala-L-Val moiety in common, while guadinomic acid is a smaller molecule consisting of a carbamoylated cyclic guanidinyl moiety and a hydroxyl hexanoate moiety.Entities:
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Year: 2008 PMID： 18503202 DOI： 10.1038/ja.2008.33
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649