Literature DB >> 29893133

Total Synthesis of (+)-Guadinomic Acid via Hydroxyl-Directed Guanidylation.

Bradley T Reid1, Artur K Mailyan1, Armen Zakarian1.   

Abstract

Protecting-group-free total synthesis of (+)-guadinomic acid is reported using δ-valerolactone as a readily available starting material. The protocol utilizes the recent hydroxyl-directed guanidylation of unactivated alkenes as an approach for direct stereoselective incorporation of the guanidine unit furnishing the natural product in 7 steps.

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Year:  2018        PMID： 29893133      PMCID： PMC6309422          DOI： 10.1021/acs.joc.8b01214

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


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