Literature DB >> 18501203

Small molecular weight protein-protein interaction antagonists: an insurmountable challenge?

Alexander Dömling1.   

Abstract

Several years ago small molecular weight protein-protein interaction (PPI) antagonists were considered as the Mount Everest in drug discovery and generally regarded as too difficult to be targeted. However, recent industrial and academic research has produced a great number of new antagonists of diverse PPIs. This review structurally analyses small molecular weight PPI antagonists and their particular targets as well as tools to discover such compounds. Besides general discussions there will be a focus on the PPI p53/mdm2.

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Year:  2008        PMID： 18501203     DOI： 10.1016/j.cbpa.2008.04.603

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  49 in total

1.  Exhaustive fluorine scanning toward potent p53-Mdm2 antagonists.

Authors:  Yijun Huang; Siglinde Wolf; David Koes; Grzegorz M Popowicz; Carlos J Camacho; Tad A Holak; Alexander Dömling
Journal:  ChemMedChem       Date:  2011-09-27       Impact factor: 3.466

2.  Two strategies for the development of mitochondrion-targeted small molecule radiation damage mitigators.

Authors:  Jean-Claude M Rwigema; Barbara Beck; Wei Wang; Alexander Doemling; Michael W Epperly; Donna Shields; Julie P Goff; Darcy Franicola; Tracy Dixon; Marie-Céline Frantz; Peter Wipf; Yulia Tyurina; Valerian E Kagan; Hong Wang; Joel S Greenberger
Journal:  Int J Radiat Oncol Biol Phys       Date:  2011-04-13       Impact factor: 7.038

3.  Hitting on the move: Targeting intrinsically disordered protein states of the MDM2-p53 interaction.

Authors:  Constantinos G Neochoritis; Jack Atmaj; Aleksandra Twarda-Clapa; Ewa Surmiak; Lukasz Skalniak; Lisa-Maria Köhler; Damian Muszak; Katarzyna Kurpiewska; Justyna Kalinowska-Tłuścik; Barbara Beck; Tad A Holak; Alexander Dömling
Journal:  Eur J Med Chem       Date:  2019-08-06       Impact factor: 6.514

4.  Transient protein states in designing inhibitors of the MDM2-p53 interaction.

Authors:  Michal Bista; Siglinde Wolf; Kareem Khoury; Kaja Kowalska; Yijun Huang; Ewa Wrona; Marcelino Arciniega; Grzegorz M Popowicz; Tad A Holak; Alexander Dömling
Journal:  Structure       Date:  2013-10-24       Impact factor: 5.006

5.  Identification of protein-protein interaction inhibitors targeting vaccinia virus processivity factor for development of antiviral agents.

Authors:  Norbert Schormann; Charnell Inglis Sommers; Mark N Prichard; Kathy A Keith; James W Noah; Manunya Nuth; Robert P Ricciardi; Debasish Chattopadhyay
Journal:  Antimicrob Agents Chemother       Date:  2011-08-15       Impact factor: 5.191

Review 6.  Targeting Pyk2 for therapeutic intervention.

Authors:  Christopher A Lipinski; Joseph C Loftus
Journal:  Expert Opin Ther Targets       Date:  2010-01       Impact factor: 6.902

7.  Structural conservation in band 4.1, ezrin, radixin, moesin (FERM) domains as a guide to identify inhibitors of the proline-rich tyrosine kinase 2.

Authors:  Nathalie Meurice; Lei Wang; Christopher A Lipinski; Zhongbo Yang; Christopher Hulme; Joseph C Loftus
Journal:  J Med Chem       Date:  2010-01-28       Impact factor: 7.446

8.  A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products.

Authors:  Robert W Huigens; Karen C Morrison; Robert W Hicklin; Timothy A Flood; Michelle F Richter; Paul J Hergenrother
Journal:  Nat Chem       Date:  2013-01-20       Impact factor: 24.427

9.  Identifying modulators of protein-protein interactions using photonic crystal biosensors.

Authors:  James T Heeres; Seok-Ho Kim; Benjamin J Leslie; Erich A Lidstone; Brian T Cunningham; Paul J Hergenrother
Journal:  J Am Chem Soc       Date:  2009-12-30       Impact factor: 15.419

10.  The p53-MDM2/MDMX axis - A chemotype perspective.

Authors:  Kareem Khoury; Grzegorz M Popowicz; Tad A Holak; Alexander Dömling
Journal:  Medchemcomm       Date:  2011       Impact factor: 3.597
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