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Literature DB >> 21954050

Exhaustive fluorine scanning toward potent p53-Mdm2 antagonists.

Yijun Huang¹, Siglinde Wolf, David Koes, Grzegorz M Popowicz, Carlos J Camacho, Tad A Holak, Alexander Dömling.

Abstract

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2011 PMID： 21954050 PMCID： PMC3772510 DOI： 10.1002/cmdc.201100428

Source DB: PubMed Journal: ChemMedChem ISSN： 1860-7179 Impact factor: 3.466

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29 in total

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2. Aurora kinase inhibitors based on the imidazo[1,2-a]pyrazine core: fluorine and deuterium incorporation improve oral absorption and exposure.

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Review 3. Translating p53 into the clinic.

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4. Biomimetic Reductive Amination of Fluoro Aldehydes and Ketones via [1,3]-Proton Shift Reaction.(1) Scope and Limitations.

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Journal: J Org Chem Date: 1996-09-20 Impact factor: 4.354

5. Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.

Authors: Grzegorz M Popowicz; Anna Czarna; Tad A Holak
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6. Methyl-monofluorination of ibuprofen selectively increases its inhibitory activity toward cyclooxygenase-1 leading to enhanced analgesic activity and reduced gastric damage in vivo.

Authors: Hong Su; Yuli Xie; Wen-Bo Liu; Shu-Li You
Journal: Bioorg Med Chem Lett Date: 2011-05-03 Impact factor: 2.823

Review 7. The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious.

Authors: Grzegorz M Popowicz; Alexander Dömling; Tad A Holak
Journal: Angew Chem Int Ed Engl Date: 2011-02-21 Impact factor: 15.336

8. Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists.

Authors: Anna Czarna; Barbara Beck; Stuti Srivastava; Grzegorz M Popowicz; Siglinde Wolf; Yijun Huang; Michal Bista; Tad A Holak; Alexander Dömling
Journal: Angew Chem Int Ed Engl Date: 2010-07-19 Impact factor: 15.336

Review 9. Aromatic rings in chemical and biological recognition: energetics and structures.

Authors: Laura M Salonen; Manuel Ellermann; François Diederich
Journal: Angew Chem Int Ed Engl Date: 2011-04-28 Impact factor: 15.336

Review 10. Predicting and tuning physicochemical properties in lead optimization: amine basicities.

Authors: Martin Morgenthaler; Eliane Schweizer; Anja Hoffmann-Röder; Fausta Benini; Rainer E Martin; Georg Jaeschke; Björn Wagner; Holger Fischer; Stefanie Bendels; Daniel Zimmerli; Josef Schneider; François Diederich; Manfred Kansy; Klaus Müller
Journal: ChemMedChem Date: 2007-08 Impact factor: 3.466

22 in total

Review 1. Focusing on shared subpockets - new developments in fragment-based drug discovery.

Authors: Eman M M Abdelraheem; Carlos J Camacho; Alexander Dömling
Journal: Expert Opin Drug Discov Date: 2015-08-21 Impact factor: 6.098

2. Structure and Reactivity of Glycosyl Isocyanides.

Authors: Constantinos G Neochoritis; Ehsan Ghonchepour; Maryam Kazemi Miraki; Tryfon Zarganes-Tzitzikas; Katarzyna Kurpiewska; Justyna Kalinowska-Tłuścik; Alexander Dömling
Journal: European J Org Chem Date: 2018-11-22

3. Transient protein states in designing inhibitors of the MDM2-p53 interaction.

Authors: Michal Bista; Siglinde Wolf; Kareem Khoury; Kaja Kowalska; Yijun Huang; Ewa Wrona; Marcelino Arciniega; Grzegorz M Popowicz; Tad A Holak; Alexander Dömling
Journal: Structure Date: 2013-10-24 Impact factor: 5.006

4. A fluorinated indole-based MDM2 antagonist selectively inhibits the growth of p53^wt osteosarcoma cells.

Authors: Lukasz Skalniak; Aleksandra Twarda-Clapa; Constantinos G Neochoritis; Ewa Surmiak; Monika Machula; Aneta Wisniewska; Beata Labuzek; Ameena M Ali; Sylwia Krzanik; Grzegorz Dubin; Matthew Groves; Alexander Dömling; Tad A Holak
Journal: FEBS J Date: 2019-02-16 Impact factor: 5.542