Literature DB >> 18493947

What controls TOR?

Estela Jacinto1.   

Abstract

The target of rapamycin (TOR) is a protein kinase with numerous functions in cell growth control. Some of these functions can be potently inhibited by rapamycin, an immunosuppressive and potential anticancer drug. TOR exists as part of two functionally distinct protein complexes. The functions of TOR complex 1 (TORC1) are effectively inhibited by rapamycin, but the mechanism for this inhibition remains elusive. The identification of TORC2 and recent reports that rapamycin can inhibit TORC2 functions, in some cases, challenge current models of TOR regulation. This review discusses the latest findings in yeast and mammals on the possible mechanisms that control TOR activity leading to its many cellular functions . (c) 2008 IUBMB

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Year:  2008        PMID： 18493947     DOI： 10.1002/iub.56

Source DB:  PubMed          Journal:  IUBMB Life        ISSN： 1521-6543            Impact factor:   3.885


  25 in total

1.  A comprehensive glossary of autophagy-related molecules and processes (2nd edition).

Authors:  Daniel J Klionsky; Eric H Baehrecke; John H Brumell; Charleen T Chu; Patrice Codogno; Ana Marie Cuervo; Jayanta Debnath; Vojo Deretic; Zvulun Elazar; Eeva-Liisa Eskelinen; Steven Finkbeiner; Juan Fueyo-Margareto; David Gewirtz; Marja Jäättelä; Guido Kroemer; Beth Levine; Thomas J Melia; Noboru Mizushima; David C Rubinsztein; Anne Simonsen; Andrew Thorburn; Michael Thumm; Sharon A Tooze
Journal:  Autophagy       Date:  2011-11-01       Impact factor: 16.016

2.  ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).

Authors:  Audrey Carriere; Yves Romeo; Hugo A Acosta-Jaquez; Julie Moreau; Eric Bonneil; Pierre Thibault; Diane C Fingar; Philippe P Roux
Journal:  J Biol Chem       Date:  2010-11-11       Impact factor: 5.157

3.  mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression.

Authors:  Bilgen Ekim; Brian Magnuson; Hugo A Acosta-Jaquez; Jennifer A Keller; Edward P Feener; Diane C Fingar
Journal:  Mol Cell Biol       Date:  2011-05-16       Impact factor: 4.272

4.  Adaptation of HepG2 cells to a steady-state reduction in the content of protein phosphatase 6 (PP6) catalytic subunit.

Authors:  Joan M Boylan; Arthur R Salomon; Umadevi Tantravahi; Philip A Gruppuso
Journal:  Exp Cell Res       Date:  2015-05-18       Impact factor: 3.905

5.  A comprehensive glossary of autophagy-related molecules and processes.

Authors:  Daniel J Klionsky; Patrice Codogno; Ana Maria Cuervo; Vojo Deretic; Zvulun Elazar; Juan Fueyo-Margareto; David A Gewirtz; Guido Kroemer; Beth Levine; Noboru Mizushima; David C Rubinsztein; Michael Thumm; Sharon A Tooze
Journal:  Autophagy       Date:  2010-05-16       Impact factor: 16.016

6.  Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.

Authors:  Dominique Helmlinger; Samuel Marguerat; Judit Villén; Danielle L Swaney; Steven P Gygi; Jürg Bähler; Fred Winston
Journal:  EMBO J       Date:  2011-06-03       Impact factor: 11.598

7.  Mammalian target of rapamycin complex 1 (mTORC1) plays a role in Pasteurella multocida toxin (PMT)-induced protein synthesis and proliferation in Swiss 3T3 cells.

Authors:  Hammou Oubrahim; Allison Wong; Brenda A Wilson; P Boon Chock
Journal:  J Biol Chem       Date:  2012-12-07       Impact factor: 5.157

Review 8.  mTOR signaling: at the crossroads of plasticity, memory and disease.

Authors:  Charles A Hoeffer; Eric Klann
Journal:  Trends Neurosci       Date:  2009-12-04       Impact factor: 13.837

9.  Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling.

Authors:  Hilary P Glazer; Robert M Osipov; Richard T Clements; Frank W Sellke; Cesario Bianchi
Journal:  Cell Cycle       Date:  2009-06-03       Impact factor: 4.534

10.  A second-site noncomplementation screen for modifiers of Rho1 signaling during imaginal disc morphogenesis in Drosophila.

Authors:  Kistie Patch; Shannon R Stewart; Aaron Welch; Robert E Ward
Journal:  PLoS One       Date:  2009-10-23       Impact factor: 3.240
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