Literature DB >> 18493648

A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues.

Irene Kiburu1, Andrew Shurer, Lei Yan, Herman O Sintim.   

Abstract

Cyclic-di-guanylate (c-di-GMP) has emerged as a general and important signaling molecule uniquely present in bacteria: herein we provide a simple solid-phase synthesis of c-di-GMP using an automated DNA synthesizer for the majority of the synthesis.

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Year:  2008        PMID： 18493648     DOI： 10.1039/b719423d

Source DB:  PubMed          Journal:  Mol Biosyst        ISSN： 1742-2051


  12 in total

1.  Structural basis of differential ligand recognition by two classes of bis-(3'-5')-cyclic dimeric guanosine monophosphate-binding riboswitches.

Authors:  Kathryn D Smith; Carly A Shanahan; Emily L Moore; Aline C Simon; Scott A Strobel
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-25       Impact factor: 11.205

2.  Differential analogue binding by two classes of c-di-GMP riboswitches.

Authors:  Carly A Shanahan; Barbara L Gaffney; Roger A Jones; Scott A Strobel
Journal:  J Am Chem Soc       Date:  2011-09-08       Impact factor: 15.419

3.  One-flask syntheses of c-di-GMP and the [Rp,Rp] and [Rp,Sp] thiophosphate analogues.

Authors:  Barbara L Gaffney; Elizabeth Veliath; Jianwei Zhao; Roger A Jones
Journal:  Org Lett       Date:  2010-07-16       Impact factor: 6.005

4.  One-flask synthesis of cyclic diguanosine monophosphate (c-di-GMP).

Authors:  Barbara L Gaffney; Roger A Jones
Journal:  Curr Protoc Nucleic Acid Chem       Date:  2012-03

5.  Synthesis of c-di-GMP analogs with thiourea, urea, carbodiimide, and guanidinium linkages.

Authors:  Barbara L Gaffney; Roger A Jones
Journal:  Org Lett       Date:  2013-12-06       Impact factor: 6.005

6.  Structural and biochemical determinants of ligand binding by the c-di-GMP riboswitch .

Authors:  Kathryn D Smith; Sarah V Lipchock; Alison L Livingston; Carly A Shanahan; Scott A Strobel
Journal:  Biochemistry       Date:  2010-08-31       Impact factor: 3.162

7.  Convenient synthesis of a propargylated cyclic (3'-5') diguanylic acid and its "click" conjugation to a biotinylated azide.

Authors:  Andrzej Grajkowski; Jacek Cieślak; Alexei Gapeev; Christian Schindler; Serge L Beaucage
Journal:  Bioconjug Chem       Date:  2010-10-13       Impact factor: 4.774

8.  Identification of c-di-GMP derivatives resistant to an EAL domain phosphodiesterase.

Authors:  Carly A Shanahan; Barbara L Gaffney; Roger A Jones; Scott A Strobel
Journal:  Biochemistry       Date:  2013-01-03       Impact factor: 3.162

Review 9.  Cyclic di-GMP: the first 25 years of a universal bacterial second messenger.

Authors:  Ute Römling; Michael Y Galperin; Mark Gomelsky
Journal:  Microbiol Mol Biol Rev       Date:  2013-03       Impact factor: 11.056

Review 10.  The bacterial second messenger c-di-GMP: probing interactions with protein and RNA binding partners using cyclic dinucleotide analogs.

Authors:  Carly A Shanahan; Scott A Strobel
Journal:  Org Biomol Chem       Date:  2012-10-29       Impact factor: 3.876
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