Literature DB >> 1849259

Inhibition of SV40 gene expression by microinjected small antisense RNA and DNA molecules.

M Graessmann1, G Michaels, B Berg, A Graessmann.   

Abstract

We tested the impact of antisense RNA and DNA molecules on SV40 gene expression by microinjection into TC7 cells. Short antisense stretches, complementary to either hairpin or loop structures on the T antigen mRNA, inhibited T antigen synthesis. In contrast, full-length antisense RNA and DNA molecules did not effect T antigen synthesis.

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Year:  1991        PMID： 1849259      PMCID： PMC333533          DOI： 10.1093/nar/19.1.53

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  38 in total

Review 1.  The role of antisense RNA in gene regulation.

Authors:  P J Green; O Pines; M Inouye
Journal:  Annu Rev Biochem       Date:  1986       Impact factor: 23.643

2.  Constitutive and conditional suppression of exogenous and endogenous genes by anti-sense RNA.

Authors:  J G Izant; H Weintraub
Journal:  Science       Date:  1985-07-26       Impact factor: 47.728

3.  Specific and stable intron-factor interactions are established early during in vitro pre-mRNA splicing.

Authors:  B Ruskin; M R Green
Journal:  Cell       Date:  1985-11       Impact factor: 41.582

4.  Excess antisense RNA from infectious recombinant SV40 fails to inhibit expression of a transfected, interferon-inducible gene.

Authors:  S M Kerr; G R Stark; I M Kerr
Journal:  Eur J Biochem       Date:  1988-07-15

5.  Injected anti-sense RNAs specifically block messenger RNA translation in vivo.

Authors:  D A Melton
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

6.  "Early" simian-virus-40-specific RNA contains information for tumor antigen formation and chromatin replication.

Authors:  M Graessmann; A Graessman
Journal:  Proc Natl Acad Sci U S A       Date:  1976-02       Impact factor: 11.205

7.  Hormonal response region in the mouse mammary tumor virus long terminal repeat can be dissociated from the proviral promoter and has enhancer properties.

Authors:  H Ponta; N Kennedy; P Skroch; N E Hynes; B Groner
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

8.  Stable reduction of thymidine kinase activity in cells expressing high levels of anti-sense RNA.

Authors:  S K Kim; B J Wold
Journal:  Cell       Date:  1985-08       Impact factor: 41.582

9.  Inhibition of SV40 replicon function by engineered antisense RNA transcribed by RNA polymerase III.

Authors:  P A Jennings; P L Molloy
Journal:  EMBO J       Date:  1987-10       Impact factor: 11.598

10.  Translation of mRNA injected into Xenopus oocytes is specifically inhibited by antisense RNA.

Authors:  R Harland; H Weintraub
Journal:  J Cell Biol       Date:  1985-09       Impact factor: 10.539
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  2 in total

1.  Gene expression profiling: cell cycle deregulation and aneuploidy do not cause breast cancer formation in WAP-SVT/t transgenic animals.

Authors:  Andreas Klein; Eva Guhl; Raphael Zollinger; Yin-Jeh Tzeng; Ralf Wessel; Michael Hummel; Monika Graessmann; Adolf Graessmann
Journal:  J Mol Med (Berl)       Date:  2005-01-21       Impact factor: 4.599

Review 2.  Progress towards in vivo use of siRNAs.

Authors:  Mark A Behlke
Journal:  Mol Ther       Date:  2006-02-14       Impact factor: 11.454
  2 in total

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