Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 "Early" simian-virus-40-specific RNA contains information for tumor antigen formation and chromatin replication.

Literature DB >> 174105

"Early" simian-virus-40-specific RNA contains information for tumor antigen formation and chromatin replication.

Abstract

Simian virus 40 (SV40) induces tumor (T)-antigen formation, chromatin replication, and mitosis in primary mouse kidney cells arrested in G0 phase of the mitotic cycle. The temporal and quantitative relation between these early virus-specific reactions led to the hypothesis that the early SV40 mRNA contains information necessary for T-antigen formation and induction of cellular DNA synthesis. To get direct experimental evidence for this hypothesis, the early strand of SV40 DNA was transcribed in vitro by Escherichia coli DNA-dependent RNA polymerase and the SV40-specific cRNA was transferred by microinjection into epitheloid cells of confluent primary mouse kidney cultures. T-antigen formation and stimulation of DNA synthesis were investigated in the recipient cells. The experimental results obtained agree with the hypothesis that T-antigen is a virus-coded protein and that the early virus-specific mRNA contains information necessary for stimulation of cellular DNA replication in the arrested cells.

Entities: Disease Species

Mesh：

Substances：

Year: 1976 PMID： 174105 PMCID： PMC335909 DOI： 10.1073/pnas.73.2.366

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

15 in total

1. SV-40 INDUCED PROLIFERATION OF TISSUE CULTURE CELLS OF RABBIT, MOUSE, AND PORCINE ORIGIN.

Authors: P H BLACK; W P ROWE
Journal: Proc Soc Exp Biol Med Date: 1963-12

2. Purification of polyoma virus.

Authors: E WINOCOUR
Journal: Virology Date: 1963-02 Impact factor: 3.616

3. The net hydration of T-4 bacteriophage deoxyribonuecleic acid and the effect of hydration on buoyant behavior in a density gradient at equilibrium in the ultracentrifuge.

Authors: J E HEARST; J VINOGRAD
Journal: Proc Natl Acad Sci U S A Date: 1961-07-15 Impact factor: 11.205

4. A simplifying concept in tumor virology: virus-specific "pleiotropic effectors".

Authors: R Weil; E Salomon; E May; P May
Journal: Cold Spring Harb Symp Quant Biol Date: 1975

5. Size of the RNA's synthesized by purified calf thymus DNA-dependent RNA polymerases on SV40 DNA.

Authors: J L Mandel; C Kedinger; F Gissinger; P Chambon
Journal: FEBS Lett Date: 1973-01-15 Impact factor: 4.124

6. [Microsurgical cell nucleus transplantation in mammalian cells].

Authors: A Grässman
Journal: Exp Cell Res Date: 1970-06 Impact factor: 3.905

7. A dye-buoyant-density method for the detection and isolation of closed circular duplex DNA: the closed circular DNA in HeLa cells.

Authors: R Radloff; W Bauer; J Vinograd
Journal: Proc Natl Acad Sci U S A Date: 1967-05 Impact factor: 11.205

8. [The formation of melanin in muscle cells after the direct transfer of RNA from Harding-Passey melanoma cells].

Authors: A Grässmann; M Grässmann
Journal: Hoppe Seylers Z Physiol Chem Date: 1971-04

9. Density heterogeneity of simian virus 40 ribonucleic acid late after infection of permissive cells.

Authors: A H Fried
Journal: J Virol Date: 1972-12 Impact factor: 5.103

10. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

Authors: H Aviv; P Leder
Journal: Proc Natl Acad Sci U S A Date: 1972-06 Impact factor: 11.205

107 in total

1. Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm.

Authors: T Seki; K Yamashita; H Nishitani; T Takagi; P Russell; T Nishimoto
Journal: Mol Biol Cell Date: 1992-12 Impact factor: 4.138

2. Density dependent inhibition of both growth and T-antigen expression in revertants isolated from simian virus 40-transformed mouse SVT2 cells.

Authors: E G Gurney; T Gurney
Journal: J Virol Date: 1979-11 Impact factor: 5.103

10. Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1.

Authors: Ian N Fleming; Ian H Batty; Alan R Prescott; Alex Gray; Gursant S Kular; Hazel Stewart; C Peter Downes
Journal: Biochem J Date: 2004-09-15 Impact factor: 3.857

"Early" simian-virus-40-specific RNA contains information for tumor antigen formation and chromatin replication.

1. SV-40 INDUCED PROLIFERATION OF TISSUE CULTURE CELLS OF RABBIT, MOUSE, AND PORCINE ORIGIN.

2. Purification of polyoma virus.

3. The net hydration of T-4 bacteriophage deoxyribonuecleic acid and the effect of hydration on buoyant behavior in a density gradient at equilibrium in the ultracentrifuge.

4. A simplifying concept in tumor virology: virus-specific "pleiotropic effectors".

5. Size of the RNA's synthesized by purified calf thymus DNA-dependent RNA polymerases on SV40 DNA.

6. [Microsurgical cell nucleus transplantation in mammalian cells].

7. A dye-buoyant-density method for the detection and isolation of closed circular duplex DNA: the closed circular DNA in HeLa cells.

8. [The formation of melanin in muscle cells after the direct transfer of RNA from Harding-Passey melanoma cells].

9. Density heterogeneity of simian virus 40 ribonucleic acid late after infection of permissive cells.

10. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

1. Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm.

2. Density dependent inhibition of both growth and T-antigen expression in revertants isolated from simian virus 40-transformed mouse SVT2 cells.

3. Gene transfer into mammalian cells by rapid freezing.

4. Enzymatic activities associated with a purified simian virus 40 T antigen-related protein.

5. Sequence requirements for synthetic peptide-mediated translocation to the nucleus.

6. Dynamic aspects of intermediate filament networks in BHK-21 cells.

7. Inhibition of SV40 gene expression by microinjected small antisense RNA and DNA molecules.

8. The translational mobility of substances within the cytoplasmic matrix.

9. Isolation and characterization of four adenovirus type 12-transformed human embryo kidney cell lines.

10. Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1.