Literature DB >> 1849030

RAR-alpha gene rearrangements as a genetic marker for diagnosis and monitoring in acute promyelocytic leukemia.

A Biondi1, A Rambaldi, M Alcalay, P P Pandolfi, F Lo Coco, D Diverio, V Rossi, A Mencarelli, L Longo, D Zangrilli.   

Abstract

Acute promyelocytic leukemias (APLs) are characterized by a translocation that involves chromosomes 15 and 17. The translocation breakpoints have recently been identified and shown to involve the RAR-alpha gene on 17 and myl on 15. Here we report Southern blotting analysis of 26 APLs, including cases with normal karyotypes and atypical morphology, which showed RAR-alpha rearrangements in 92% cases, myl rearrangements in 73%, and either RAR-alpha or myl rearrangements in 100%. Despite a negative clinical and morphologic picture, DNA rearrangement analysis showed that neoplastic promyelocytes persisted in the bone marrow of two patients sampled after induction chemotherapy. Therefore, the RAR-alpha and myl rearrangements provide molecular markers for accurately diagnosing APLs and monitoring the course of the disease during and after chemotherapy.

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Year:  1991        PMID： 1849030

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  12 in total

1.  Phosphorylation of c-Cbl and p85 PI3K driven by all-trans retinoic acid and CD38 depends on Lyn kinase activity.

Authors:  Johanna Congleton; Miaoqing Shen; Robert MacDonald; Fabio Malavasi; Andrew Yen
Journal:  Cell Signal       Date:  2014-03-29       Impact factor: 4.315

2.  Detection of minimal residual disease in leukaemia.

Authors:  F E Katz
Journal:  Arch Dis Child       Date:  1992-06       Impact factor: 3.791

Review 3.  The molecular genetics of hematologic malignancies.

Authors:  A Bagg
Journal:  Clin Diagn Lab Immunol       Date:  1995-05

4.  A PML/RARA chimeric gene on chromosome 12 in a patient with acute promyelocytic leukemia (M4) associated with a new variant translocation: t(12;15;17)(q24;q24;q11).

Authors:  Ayda Bennour; Ikram Tabka; Yosra Ben Youssef; Monia Zaier; Sondess Hizem; Abderrahim Khelif; Ali Saad; Halima Sennana
Journal:  Med Oncol       Date:  2013-01-06       Impact factor: 3.064

Review 5.  Global characteristics of childhood acute promyelocytic leukemia.

Authors:  L Zhang; A Samad; M S Pombo-de-Oliveira; G Scelo; M T Smith; J Feusner; J L Wiemels; C Metayer
Journal:  Blood Rev       Date:  2014-09-30       Impact factor: 8.250

6.  Correlation of differentiation-inducing activity of retinoids on human leukemia cell lines HL-60 and NB4.

Authors:  Y Hashimoto; H Kagechika; E Kawachi; H Fukasawa; G Saito; K Shudo
Journal:  J Cancer Res Clin Oncol       Date:  1995       Impact factor: 4.553

Review 7.  Monitoring PML-RARalpha in acute promyelocytic leukemia.

Authors:  Joseph G Jurcic
Journal:  Curr Oncol Rep       Date:  2003-09       Impact factor: 5.075

8.  Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia.

Authors:  W H Miller; A Kakizuka; S R Frankel; R P Warrell; A DeBlasio; K Levine; R M Evans; E Dmitrovsky
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-01       Impact factor: 11.205

9.  c-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic acid-induced cell differentiation and G0 arrest.

Authors:  Miaoqing Shen; Andrew Yen
Journal:  J Biol Chem       Date:  2009-07-27       Impact factor: 5.157

10.  Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.

Authors:  M Alcalay; D Zangrilli; M Fagioli; P P Pandolfi; A Mencarelli; F Lo Coco; A Biondi; F Grignani; P G Pelicci
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205
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