Literature DB >> 12895391

Monitoring PML-RARalpha in acute promyelocytic leukemia.

Joseph G Jurcic1.   

Abstract

Acute promyelocytic leukemia (APL) is characterized by a translocation between the promyelocytic leukemia gene (PML) on chromosome 15 and the retinoic acid receptor-alpha (RARalpha) gene on chromosome 17. Reverse-transcription polymerase chain reaction (RT-PCR) amplification of PML-RARalpha messenger RNA can establish the diagnosis of APL, predict response to all-trans retinoic acid and arsenic trioxide, detect minimal residual disease, and predict relapse. Quantitative "real-time" RT-PCR techniques may improve residual disease assessment by facilitating more rapid and standardized results. APL provides a useful model in which therapy is targeted to an underlying genetic aberration and treatment is adapted based on monitoring of residual disease.

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Year:  2003        PMID： 12895391     DOI： 10.1007/s11912-003-0025-7

Source DB:  PubMed          Journal:  Curr Oncol Rep        ISSN： 1523-3790            Impact factor:   5.075


  65 in total

Review 1.  The pathogenesis of acute promyelocytic leukaemia: evaluation of the role of molecular diagnosis and monitoring in the management of the disease.

Authors:  D Grimwade
Journal:  Br J Haematol       Date:  1999-09       Impact factor: 6.998

2.  Quantitative real-time RT-PCR analysis of PML-RAR alpha mRNA in acute promyelocytic leukemia: assessment of prognostic significance in adult patients from intergroup protocol 0129.

Authors:  Robert E Gallagher; Beow Y Yeap; Wanli Bi; Kenneth J Livak; Nike Beaubier; Sreenivas Rao; Clara D Bloomfield; Frederick R Appelbaum; Martin S Tallman; James L Slack; Cheryl L Willman
Journal:  Blood       Date:  2002-12-05       Impact factor: 22.113

3.  Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients.

Authors:  C Niu; H Yan; T Yu; H P Sun; J X Liu; X S Li; W Wu; F Q Zhang; Y Chen; L Zhou; J M Li; X Y Zeng; R R Yang; M M Yuan; M Y Ren; F Y Gu; Q Cao; B W Gu; X Y Su; G Q Chen; S M Xiong; T D Zhang; S Waxman; Z Y Wang; Z Chen; J Hu; Z X Shen; S J Chen
Journal:  Blood       Date:  1999-11-15       Impact factor: 22.113

4.  Absence of detectable PML-RAR alpha fusion transcripts in long-term remission patients after BMT for acute promyelocytic leukemia.

Authors:  J Román; C Martín; A Torres; M A Jiménez; P Andrés; R Flores; M J de la Torre; J Sánchez; J Serrano; M Falcón
Journal:  Bone Marrow Transplant       Date:  1997-04       Impact factor: 5.483

5.  Autologous bone marrow transplantation for acute promyelocytic leukemia in second remission: prognostic relevance of pretransplant minimal residual disease assessment by reverse-transcription polymerase chain reaction of the PML/RAR alpha fusion gene.

Authors:  G Meloni; D Diverio; M Vignetti; G Avvisati; S Capria; M C Petti; F Mandelli; F Lo Coco
Journal:  Blood       Date:  1997-08-01       Impact factor: 22.113

6.  Early detection of relapse by prospective reverse transcriptase-polymerase chain reaction analysis of the PML/RARalpha fusion gene in patients with acute promyelocytic leukemia enrolled in the GIMEMA-AIEOP multicenter "AIDA" trial. GIMEMA-AIEOP Multicenter "AIDA" Trial.

Authors:  D Diverio; V Rossi; G Avvisati; S De Santis; A Pistilli; F Pane; G Saglio; G Martinelli; M C Petti; A Santoro; P G Pelicci; F Mandelli; A Biondi; F Lo Coco
Journal:  Blood       Date:  1998-08-01       Impact factor: 22.113

7.  The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion.

Authors:  R L Redner; E A Rush; S Faas; W A Rudert; S J Corey
Journal:  Blood       Date:  1996-02-01       Impact factor: 22.113

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Authors:  K Ikeda; K Sasaki; T Tasaka; M Nagai; K Kawanishi; J Takahara; S Irino
Journal:  Leukemia       Date:  1993-04       Impact factor: 11.528

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Authors:  H Fukutani; T Naoe; R Ohno; H Yoshida; H Kiyoi; S Miyawaki; H Morishita; F Sano; H Kamibayashi; K Matsue
Journal:  Leukemia       Date:  1995-04       Impact factor: 11.528

10.  Absence of reverse transcription-polymerase chain reaction detectable residual disease in patients with acute promyelocytic leukemia in long-term remission.

Authors:  D Diverio; P P Pandolfi; A Biondi; G Avvisati; M C Petti; F Mandelli; G Pelicci; F Lo Coco
Journal:  Blood       Date:  1993-12-15       Impact factor: 22.113
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  1 in total

Review 1.  Advances in the molecular genetics of acute leukemia.

Authors:  Joseph M Scandura
Journal:  Curr Oncol Rep       Date:  2005-09       Impact factor: 5.075
  1 in total

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