Literature DB >> 1317574

Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.

M Alcalay1, D Zangrilli, M Fagioli, P P Pandolfi, A Mencarelli, F Lo Coco, A Biondi, F Grignani, P G Pelicci.   

Abstract

Two chimeric genes, PML-RAR alpha and RAR alpha-PML, are formed as a consequence of the acute promyelocytic leukemia (APL)-specific reciprocal translocation of chromosomes 15 and 17 [t(15;17)]. PML-RAR alpha is expressed as a fusion protein. We investigated the organization and expression pattern of the RAR alpha-PML gene in a series of APL patients representative of the molecular heterogeneity of the t(15;17) and found (i) two types of RAR alpha-PML mRNA junctions (RAR alpha exon 2/PML exon 4 or RAR alpha exon 2/PML exon 7) that maintain the RAR alpha and PML longest open reading frames aligned and are the result of chromosome 15 breaking at two different sites; and (ii) 10 different RAR alpha-PML fusion transcripts that differ for the assembly of their PML coding exons. A RAR alpha-PML transcript was present in most, but not all, APL patients.

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Year:  1992        PMID： 1317574      PMCID： PMC49183          DOI： 10.1073/pnas.89.11.4840

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

Review 1.  Nuclear receptors enhance our understanding of transcription regulation.

Authors:  S Green; P Chambon
Journal:  Trends Genet       Date:  1988-11       Impact factor: 11.639

2.  RAR-alpha gene rearrangements as a genetic marker for diagnosis and monitoring in acute promyelocytic leukemia.

Authors:  A Biondi; A Rambaldi; M Alcalay; P P Pandolfi; F Lo Coco; D Diverio; V Rossi; A Mencarelli; L Longo; D Zangrilli
Journal:  Blood       Date:  1991-04-01       Impact factor: 22.113

3.  Molecular evaluation of response to all-trans-retinoic acid therapy in patients with acute promyelocytic leukemia.

Authors:  F Lo Coco; G Avvisati; D Diverio; M C Petti; M Alcalay; P P Pandolfi; D Zangrilli; A Biondi; A Rambaldi; M L Moleti
Journal:  Blood       Date:  1991-04-15       Impact factor: 22.113

4.  Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus.

Authors:  M Alcalay; D Zangrilli; P P Pandolfi; L Longo; A Mencarelli; A Giacomucci; M Rocchi; A Biondi; A Rambaldi; F Lo Coco
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-01       Impact factor: 11.205

5.  The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR.

Authors:  H de Thé; C Lavau; A Marchio; C Chomienne; L Degos; A Dejean
Journal:  Cell       Date:  1991-08-23       Impact factor: 41.582

6.  Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML.

Authors:  A Kakizuka; W H Miller; K Umesono; R P Warrell; S R Frankel; V V Murty; E Dmitrovsky; R M Evans
Journal:  Cell       Date:  1991-08-23       Impact factor: 41.582

7.  Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties.

Authors:  P P Pandolfi; F Grignani; M Alcalay; A Mencarelli; A Biondi; F LoCoco; F Grignani; P G Pelicci
Journal:  Oncogene       Date:  1991-07       Impact factor: 9.867

8.  Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).

Authors:  S J Collins; K A Robertson; L Mueller
Journal:  Mol Cell Biol       Date:  1990-05       Impact factor: 4.272

9.  Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17.

Authors:  J Borrow; A D Goddard; D Sheer; E Solomon
Journal:  Science       Date:  1990-09-28       Impact factor: 47.728

10.  Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias.

Authors:  L Longo; P P Pandolfi; A Biondi; A Rambaldi; A Mencarelli; F Lo Coco; D Diverio; L Pegoraro; G Avanzi; A Tabilio
Journal:  J Exp Med       Date:  1990-12-01       Impact factor: 14.307
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  20 in total

1.  Clinical significance of increased PML-RARa transcripts after induction therapy for acute promyelocytic leukaemia.

Authors:  Mi Liang; Lei Wang; Min Xiao; Jie Xiong; Jin Wang; Zhiqiong Wang; Wei Huang; Jianfeng Zhou
Journal:  Ann Med       Date:  2020-04-23       Impact factor: 4.709

2.  A retrovirus carrying the promyelocyte-retinoic acid receptor PML-RARalpha fusion gene transforms haematopoietic progenitors in vitro and induces acute leukaemias.

Authors:  M Altabef; M Garcia; C Lavau; S C Bae; A Dejean; J Samarut
Journal:  EMBO J       Date:  1996-06-03       Impact factor: 11.598

3.  A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia.

Authors:  J L Pollock; P Westervelt; A K Kurichety; P G Pelicci; J L Grisolano; T J Ley
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

4.  Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice.

Authors:  L Z He; C Tribioli; R Rivi; D Peruzzi; P G Pelicci; V Soares; G Cattoretti; P P Pandolfi
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-13       Impact factor: 11.205

5.  CD79 alpha expression in acute myeloid leukemia. High frequency of expression in acute promyelocytic leukemia.

Authors:  D A Arber; K A Jenkins; M L Slovak
Journal:  Am J Pathol       Date:  1996-10       Impact factor: 4.307

6.  The roles of bioactive sphingolipids in resveratrol-induced apoptosis in HL60: acute myeloid leukemia cells.

Authors:  Zeynep Cakir; Guray Saydam; Fahri Sahin; Yusuf Baran
Journal:  J Cancer Res Clin Oncol       Date:  2010-04-18       Impact factor: 4.553

7.  Use of whole-genome sequencing to diagnose a cryptic fusion oncogene.

Authors:  John S Welch; Peter Westervelt; Li Ding; David E Larson; Jeffery M Klco; Shashikant Kulkarni; John Wallis; Ken Chen; Jacqueline E Payton; Robert S Fulton; Joelle Veizer; Heather Schmidt; Tammi L Vickery; Sharon Heath; Mark A Watson; Michael H Tomasson; Daniel C Link; Timothy A Graubert; John F DiPersio; Elaine R Mardis; Timothy J Ley; Richard K Wilson
Journal:  JAMA       Date:  2011-04-20       Impact factor: 56.272

8.  Quantitative detection of PML-RARalpha fusion transcript by real-time PCR with a single primer pair.

Authors:  Mariko Takenokuchi; Yuji Nakamachi; Keiko Yoneda; Kana Joo; Seiji Kawano; Eiji Tatsumi; Katsuyasu Saigo; Shunichi Kumagai
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9.  Value of oligonucleotide-based array comparative genomic hybridization for diagnosis of acute promyelocytic leukemia in a patient negative for t(15;17)(q24.1;q21.2)/promyelocytic leukemia-retinoic acid receptor, alpha by conventional cytogenetics and fluorescence in situ hybridization.

Authors:  Khaled Alayed; L Jeffrey Medeiros; Roger A Schultz; Jorge Cortes; Gary Lu; Carlos E Bueso-Ramos; Sergej Konoplev
Journal:  Clin Lymphoma Myeloma Leuk       Date:  2013-06-14

10.  Expression of Human Cytomegalovirus IE1 Leads to Accumulation of Mono-SUMOylated PML That Is Protected from Degradation by Herpes Simplex Virus 1 ICP0.

Authors:  Wangheng Hou; Ruth Cruz-Cosme; Fayuan Wen; Jin-Hyun Ahn; Inez Reeves; Min-Hua Luo; Qiyi Tang
Journal:  J Virol       Date:  2018-11-12       Impact factor: 5.103
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