F K Assah1, S Brage, U Ekelund, N J Wareham. 1. MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Box 285, Hills Road, Cambridge, CB2 0QQ, UK.
Abstract
AIMS/HYPOTHESIS: Physical activity is important in preventing insulin resistance, but it is unclear which dimension of activity confers this benefit. We examined the association of overall level and intensity of physical activity with fasting insulin level, a marker of insulin resistance. METHODS: This was a cross-sectional analysis of the Medical Research Council Ely population-based cohort study (2000--2002). Physical activity energy expenditure (PAEE) in kJ kg(-1) min(-1) was measured by heart rate monitoring with individual calibration over a period of 4 days. The percentage of time spent above 1.5, 1.75 and 2 times resting heart rate (RHR) represented all light-to-vigorous, moderate-to-vigorous and vigorous activity, respectively. RESULTS: Data from a total of 643 non-diabetic individuals (319 men, 324 women) aged 50 to 75 years were analysed. In multivariate linear regression analyses, adjusting for age, sex and body fat percentage, PAEE was significantly associated with fasting insulin (pmol/l) (beta = -0.875, p = 0.006). Time (% of total) spent above 1.75 x RHR and also time spent above 2 x RHR were both significantly associated with fasting insulin (beta = -0.0109, p = 0.007 and beta = -0.0365, p = 0.001 respectively), after adjusting for PAEE, age, sex and body fat percentage. Time spent above 1.5 x RHR was not significantly associated with fasting insulin in a similar model (beta = -0.0026, p = 0.137). CONCLUSIONS/ INTERPRETATION: The association between PAEE and fasting insulin level, a marker of insulin resistance, may be attributable to the time spent in moderate-to-vigorous and vigorous activity, but not to time spent in light-intensity physical activity.
AIMS/HYPOTHESIS: Physical activity is important in preventing insulin resistance, but it is unclear which dimension of activity confers this benefit. We examined the association of overall level and intensity of physical activity with fasting insulin level, a marker of insulin resistance. METHODS: This was a cross-sectional analysis of the Medical Research Council Ely population-based cohort study (2000--2002). Physical activity energy expenditure (PAEE) in kJ kg(-1) min(-1) was measured by heart rate monitoring with individual calibration over a period of 4 days. The percentage of time spent above 1.5, 1.75 and 2 times resting heart rate (RHR) represented all light-to-vigorous, moderate-to-vigorous and vigorous activity, respectively. RESULTS: Data from a total of 643 non-diabetic individuals (319 men, 324 women) aged 50 to 75 years were analysed. In multivariate linear regression analyses, adjusting for age, sex and body fat percentage, PAEE was significantly associated with fasting insulin (pmol/l) (beta = -0.875, p = 0.006). Time (% of total) spent above 1.75 x RHR and also time spent above 2 x RHR were both significantly associated with fasting insulin (beta = -0.0109, p = 0.007 and beta = -0.0365, p = 0.001 respectively), after adjusting for PAEE, age, sex and body fat percentage. Time spent above 1.5 x RHR was not significantly associated with fasting insulin in a similar model (beta = -0.0026, p = 0.137). CONCLUSIONS/ INTERPRETATION: The association between PAEE and fasting insulin level, a marker of insulin resistance, may be attributable to the time spent in moderate-to-vigorous and vigorous activity, but not to time spent in light-intensity physical activity.
Authors: Beverley Balkau; Marie-Aline Charles; Thomas Drivsholm; Knut Borch-Johnsen; Nick Wareham; John S Yudkin; Richard Morris; Ivana Zavaroni; Rob van Dam; Edith Feskins; Rafael Gabriel; Malmö Diet; Peter Nilsson; Bo Hedblad Journal: Diabetes Metab Date: 2002-11 Impact factor: 6.041
Authors: P W Franks; J Luan; P O Browne; A-H Harding; S O'Rahilly; V K K Chatterjee; N J Wareham Journal: Metabolism Date: 2004-01 Impact factor: 8.694
Authors: Joseph A Houmard; Charles J Tanner; Cris A Slentz; Brian D Duscha; Jennifer S McCartney; William E Kraus Journal: J Appl Physiol (1985) Date: 2003-09-12
Authors: Mohammed F Saad; Marian Rewers; Joseph Selby; George Howard; Sujata Jinagouda; Salwa Fahmi; Dan Zaccaro; Richard N Bergman; Peter J Savage; Steven M Haffner Journal: Hypertension Date: 2004-05-03 Impact factor: 10.190
Authors: David E Laaksonen; Hanna-Maaria Lakka; Jukka T Salonen; Leo K Niskanen; Rainer Rauramaa; Timo A Lakka Journal: Diabetes Care Date: 2002-09 Impact factor: 19.112
Authors: Timo A Lakka; David E Laaksonen; Hanna-Maaria Lakka; Niko Männikkö; Leo K Niskanen; Rainer Rauramaa; Jukka T Salonen Journal: Med Sci Sports Exerc Date: 2003-08 Impact factor: 5.411
Authors: Jose P Silva; Ferdinand von Meyenn; Jessica Howell; Bernard Thorens; Christian Wolfrum; Markus Stoffel Journal: Nature Date: 2009-12-03 Impact factor: 49.962
Authors: Steven C Moore; Tricia M Peters; Jiyoung Ahn; Yikyung Park; Arthur Schatzkin; Demetrius Albanes; Rachel Ballard-Barbash; Albert Hollenbeck; Michael F Leitzmann Journal: Cancer Epidemiol Biomarkers Prev Date: 2008-08-25 Impact factor: 4.254
Authors: Anna Gradmark; Jeremy Pomeroy; Frida Renström; Susanne Steiginga; Margareta Persson; Antony Wright; Les Bluck; Magnus Domellöf; Steven E Kahn; Ingrid Mogren; Paul W Franks Journal: BMC Pregnancy Childbirth Date: 2011-06-16 Impact factor: 3.007