Literature DB >> 18481990

Regulation of gene expression by the RNA-binding protein Sam68 in cancer.

Prabhakar Rajan1, Luke Gaughan, Caroline Dalgliesh, Amira El-Sherif, Craig N Robson, Hing Y Leung, David J Elliott.   

Abstract

Sam68 (Src-associated in mitosis 68 kDa) is the prototypical member of the STAR (signal transducer and activator of RNA) family of RNA-binding proteins. Sam68 is implicated in a number of cellular processes including signal transduction, transcription, RNA metabolism, cell cycle regulation and apoptosis. In the present review, we summarize the functions of Sam68 as a transcriptional and post-transcriptional regulator of gene expression, with particular relevance to cancer.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18481990     DOI： 10.1042/BST0360505

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  22 in total

1.  Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence.

Authors:  Y Tang; I Horikawa; M Ajiro; A I Robles; K Fujita; A M Mondal; J K Stauffer; Z-M Zheng; C C Harris
Journal:  Oncogene       Date:  2012-07-09       Impact factor: 9.867

2.  Sam68 regulates cell proliferation and cell adhesion-mediated drug resistance (CAM-DR) via the AKT pathway in non-Hodgkin's lymphoma.

Authors:  Yaxun Wu; Xiaohong Xu; Xiaobing Miao; Xinghua Zhu; Haibing Yin; Yunhua He; Chunsun Li; Yushan Liu; Yali Chen; Xiaoyun Lu; Yuchan Wang; Song He
Journal:  Cell Prolif       Date:  2015-10-19       Impact factor: 6.831

Review 3.  Networking in a global world: establishing functional connections between neural splicing regulators and their target transcripts.

Authors:  John A Calarco; Mei Zhen; Benjamin J Blencowe
Journal:  RNA       Date:  2011-03-17       Impact factor: 4.942

Review 4.  MicroRNA regulation by RNA-binding proteins and its implications for cancer.

Authors:  Marieke van Kouwenhove; Martijn Kedde; Reuven Agami
Journal:  Nat Rev Cancer       Date:  2011-08-05       Impact factor: 60.716

5.  Sam68 promotes cellular proliferation and predicts poor prognosis in esophageal squamous cell carcinoma.

Authors:  Yayun Wang; Li Liang; Jianguo Zhang; Mei Li; Junya Zhu; Chen Gong; Linlin Yang; Jia Zhu; Lingling Chen; Runzhou Ni
Journal:  Tumour Biol       Date:  2015-06-07

6.  High Sam68 expression predicts poor prognosis in non-small cell lung cancer.

Authors:  Z Zhang; Y Xu; N Sun; M Zhang; J Xie; Z Jiang
Journal:  Clin Transl Oncol       Date:  2014-02-13       Impact factor: 3.405

7.  Bortezomib induces the formation of nuclear poly(A) RNA granules enriched in Sam68 and PABPN1 in sensory ganglia neurons.

Authors:  Iñigo Casafont; Maria T Berciano; Miguel Lafarga
Journal:  Neurotox Res       Date:  2009-07-16       Impact factor: 3.911

Review 8.  Chromatin dynamics associated with HIV-1 Tat-activated transcription.

Authors:  Rebecca Easley; Rachel Van Duyne; Will Coley; Irene Guendel; Sherry Dadgar; Kylene Kehn-Hall; Fatah Kashanchi
Journal:  Biochim Biophys Acta       Date:  2009-08-27

9.  The serine/arginine-rich protein SF2/ASF regulates protein sumoylation.

Authors:  Federico Pelisch; Juan Gerez; Jimena Druker; Ignacio E Schor; Manuel J Muñoz; Guillermo Risso; Ezequiel Petrillo; Belinda J Westman; Angus I Lamond; Eduardo Arzt; Anabella Srebrow
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-30       Impact factor: 11.205

10.  Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells.

Authors:  Kai Fu; Xin Sun; Wenxin Zheng; Eric M Wier; Andrea Hodgson; Dat Q Tran; Stéphane Richard; Fengyi Wan
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.