Literature DB >> 18480899

Epigenetic remodeling of the fungal secondary metabolome.

Russell B Williams1, Jon C Henrikson, Ashley R Hoover, Andrlynn E Lee, Robert H Cichewicz.   

Abstract

Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited natural product profiles with enhanced chemical diversity demonstrating that small-molecule epigenetic modifiers are effective tools for rationally controlling the native expression of fungal biosynthetic pathways and generating new biomolecules.

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Year:  2008        PMID： 18480899     DOI： 10.1039/b804701d

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  92 in total

1.  Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an atlantic-forest-soil-derived Penicillium citreonigrum.

Authors:  Xiaoru Wang; José G Sena Filho; Ashley R Hoover; Jarrod B King; Trevor K Ellis; Douglas R Powell; Robert H Cichewicz
Journal:  J Nat Prod       Date:  2010-05-28       Impact factor: 4.050

2.  Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans.

Authors:  Xiaoru Wang; Jianlan You; Jarrod B King; Douglas R Powell; Robert H Cichewicz
Journal:  J Nat Prod       Date:  2012-03-08       Impact factor: 4.050

3.  Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster.

Authors:  Sebastian Bergmann; Alexander N Funk; Kirstin Scherlach; Volker Schroeckh; Ekaterina Shelest; Uwe Horn; Christian Hertweck; Axel A Brakhage
Journal:  Appl Environ Microbiol       Date:  2010-10-15       Impact factor: 4.792

Review 4.  Strategies for mining fungal natural products.

Authors:  Philipp Wiemann; Nancy P Keller
Journal:  J Ind Microbiol Biotechnol       Date:  2013-10-22       Impact factor: 3.346

Review 5.  Fungal secondary metabolism: regulation, function and drug discovery.

Authors:  Nancy P Keller
Journal:  Nat Rev Microbiol       Date:  2019-03       Impact factor: 60.633

6.  Hidden biosynthetic treasures brought to light.

Authors:  Christian Hertweck
Journal:  Nat Chem Biol       Date:  2009-07       Impact factor: 15.040

7.  HdaA, a class 2 histone deacetylase of Aspergillus fumigatus, affects germination and secondary metabolite production.

Authors:  Inhyung Lee; Jee-Hwan Oh; E Keats Shwab; Taylor R T Dagenais; David Andes; Nancy P Keller
Journal:  Fungal Genet Biol       Date:  2009-06-27       Impact factor: 3.495

8.  Two histone deacetylases, FfHda1 and FfHda2, are important for Fusarium fujikuroi secondary metabolism and virulence.

Authors:  L Studt; F J Schmidt; L Jahn; C M K Sieber; L R Connolly; E-M Niehaus; M Freitag; H-U Humpf; B Tudzynski
Journal:  Appl Environ Microbiol       Date:  2013-10-04       Impact factor: 4.792

Review 9.  Unlocking fungal cryptic natural products.

Authors:  Yi-Ming Chiang; Kuan-Han Lee; James F Sanchez; Nancy P Keller; Clay C C Wang
Journal:  Nat Prod Commun       Date:  2009-11       Impact factor: 0.986

10.  Restoration of camptothecine production in attenuated endophytic fungus on re-inoculation into host plant and treatment with DNA methyltransferase inhibitor.

Authors:  M M Vasanthakumari; S S Jadhav; Naik Sachin; G Vinod; Singh Shweta; B L Manjunatha; P Mohana Kumara; G Ravikanth; Karaba N Nataraja; R Uma Shaanker
Journal:  World J Microbiol Biotechnol       Date:  2015-08-20       Impact factor: 3.312
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