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Literature DB >> 1848043

Susceptibility to Coxsackievirus B3-induced chronic myocarditis maps near the murine Tcr alpha and Myhc alpha loci on chromosome 14.

M D Traystman¹, L H Chow, B M McManus, A Herskowitz, M N Nesbitt, K W Beisel.

Abstract

This study was undertaken to determine the genetic control of host susceptibility to coxsackievirus B3 (CVB3)-induced chronic myocarditis in a mouse model. An autosomal recessive autoimmune myocardial disease (amd) gene (possibly more than one gene), which determined susceptibility to CVB3-induced chronic myocarditis in the A/J and DBA/2J inbred mouse strains, was mapped to a segment of chromosome 14. Data from both the AXB/BXA recombinant inbred (RI) strains and the B10.D2(57N) H-8b congenic mice supported this linkage relationship. Analysis of the AXB/BXA RI strain distribution patterns suggested that amd maps distal to the Np-2, Tcr alpha, and Myhc alpha loci.

Entities: Chemical Disease Gene Species

Mesh：

Year: 1991 PMID： 1848043 PMCID： PMC1886275

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

25 in total

Review 1. A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation.

Authors: Y H Chien; M Iwashima; K B Kaplan; J F Elliott; M M Davis
Journal: Nature Date: 1987 Jun 25-Jul 1 Impact factor: 49.962

2. Postinfectious autoimmunity: two distinct phases of coxsackievirus B3-induced myocarditis.

Authors: N R Rose; L J Wolfgram; A Herskowitz; K W Beisel
Journal: Ann N Y Acad Sci Date: 1986 Impact factor: 5.691

3. Coxsackievirus-induced disease. CD4+ cells initiate both myocarditis and pancreatitis in DBA/2 mice.

Authors: R Blay; K Simpson; K Leslie; S Huber
Journal: Am J Pathol Date: 1989-11 Impact factor: 4.307

Review 4. The T-cell receptor repertoire and autoimmune diseases.

Authors: V Kumar; D H Kono; J L Urban; L Hood
Journal: Annu Rev Immunol Date: 1989 Impact factor: 28.527

5. Coxsackievirus B3 murine myocarditis: a pathologic spectrum of myocarditis in genetically defined inbred strains.

Authors: A Herskowitz; L J Wolfgram; N R Rose; K W Beisel
Journal: J Am Coll Cardiol Date: 1987-06 Impact factor: 24.094

6. Autoantibodies specific for the cardiac myosin isoform are found in mice susceptible to Coxsackievirus B3-induced myocarditis.

Authors: N Neu; K W Beisel; M D Traystman; N R Rose; S W Craig
Journal: J Immunol Date: 1987-04-15 Impact factor: 5.422

7. Coxsackievirus B-3 myocarditis. Identification of different pathogenic mechanisms in DBA/2 and Balb/c mice.

Authors: S A Huber; P A Lodge
Journal: Am J Pathol Date: 1986-02 Impact factor: 4.307

8. Coxsackievirus B-3 myocarditis. Acute and chronic forms of the disease caused by different immunopathogenic mechanisms.

Authors: P A Lodge; M Herzum; J Olszewski; S A Huber
Journal: Am J Pathol Date: 1987-09 Impact factor: 4.307

9. The cytotoxic T cell response to the male-specific histocompatibility antigen (H-Y) is controlled by two dominant immune response genes, one in the MHC, the other in the Tar alpha-locus.

Authors: R Epstein; G Sham; J Womack; J Yagüe; E Palmer; M Cohn
Journal: J Exp Med Date: 1986-04-01 Impact factor: 14.307

10. Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis.

Authors: L J Wolfgram; K W Beisel; N R Rose
Journal: J Exp Med Date: 1985-05-01 Impact factor: 14.307

7 in total

Review 1. Mouse chromosome 14.

Authors: J H Nadeau; R Cox
Journal: Mamm Genome Date: 1992 Impact factor: 2.957

Susceptibility to Coxsackievirus B3-induced chronic myocarditis maps near the murine Tcr alpha and Myhc alpha loci on chromosome 14.

Review 1. A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation.

2. Postinfectious autoimmunity: two distinct phases of coxsackievirus B3-induced myocarditis.

3. Coxsackievirus-induced disease. CD4+ cells initiate both myocarditis and pancreatitis in DBA/2 mice.

Review 4. The T-cell receptor repertoire and autoimmune diseases.

5. Coxsackievirus B3 murine myocarditis: a pathologic spectrum of myocarditis in genetically defined inbred strains.

6. Autoantibodies specific for the cardiac myosin isoform are found in mice susceptible to Coxsackievirus B3-induced myocarditis.

7. Coxsackievirus B-3 myocarditis. Identification of different pathogenic mechanisms in DBA/2 and Balb/c mice.

8. Coxsackievirus B-3 myocarditis. Acute and chronic forms of the disease caused by different immunopathogenic mechanisms.

9. The cytotoxic T cell response to the male-specific histocompatibility antigen (H-Y) is controlled by two dominant immune response genes, one in the MHC, the other in the Tar alpha-locus.

10. Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis.

Review 1. Mouse chromosome 14.

2. Host modifier genes affect mouse autoimmunity induced by the lpr gene.

3. Mapping of a quantitative trait locus controlling susceptibility to Coxsackievirus B3-induced viral hepatitis.

4. Apolipoprotein J/clusterin induction in myocarditis: A localized response gene to myocardial injury.

5. Genetic control of Coxsackievirus B3-induced heart-specific autoantibodies associated with chronic myocarditis.

6. Cardiac alpha-myosin heavy chains differ in their induction of myocarditis. Identification of pathogenic epitopes.

Review 7. Autoimmunity in Acute Myocarditis: How Immunopathogenesis Steers New Directions for Diagnosis and Treatment.