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Literature DB >> 2985729

Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis.

Abstract

The sera from A.SW/SnJ mice infected with Coxsackievirus B3 (CB3) were tested on normal mouse tissue by indirect immunofluorescence. Heart-reactive antibodies were found. Absorption studies with organ extracts showed some of these autoantibodies to be heart-specific. Additional antibodies were crossreactive with skeletal muscle and kidney. These findings suggest a role for autoimmunity in the pathogenesis of murine CB3-induced myocarditis. This study establishes an animal model for the study of the humoral autoimmune response in human viral myocarditis.

Entities: Disease Species

Mesh：

Substances：
Autoantibodies

Year: 1985 PMID： 2985729 PMCID： PMC2187616 DOI： 10.1084/jem.161.5.1112

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

16 in total

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42 in total

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