Literature DB >> 18475452

Interaction between PAF and human platelet membranes: a fluorescence study.

A Kantar1, P L Giorgi, G Curatola, R Fiorini.   

Abstract

The interaction between PAF and human platelet membranes was investigated by measuring the steadystate fluorescence anisotropy and fluorescence decay of 1 (4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene (TMA-DPH) incorporated in platelet plasma membranes. PAF induced a time-limited and significant increase of the lipid order in the exterior part of the membrane and a decrease in membrane heterogeneity. These changes were blocked in the presence of the PAF antagonists, L-659,989 and 1-O-hexadecyl-2-acetyl-sn-glycero-3-phospho(N,N,N-trimethyl)hexanolamine.H(2)O. These results indicate that the observed changes in the physico-chemical properties of the membrane are attributed to the PAF-receptor interaction and signal transduction.

Entities:  

Year:  1992        PMID： 18475452      PMCID： PMC2365332          DOI： 10.1155/S0962935192000218

Source DB:  PubMed          Journal:  Mediators Inflamm        ISSN： 0962-9351            Impact factor:   4.711


  28 in total

Review 1.  PAF. A review of its effects, antagonists and possible future clinical implications (Part II).

Authors:  M Koltai; D Hosford; P Guinot; A Esanu; P Braquet
Journal:  Drugs       Date:  1991-08       Impact factor: 9.546

2.  Comparisons of steady-state anisotropy of the plasma membrane of living cells with different probes.

Authors:  J M Collins; W M Grogan
Journal:  Biochim Biophys Acta       Date:  1991-08-26

3.  Modulation of cytoplasmic calcium in human platelets by the phospholipid platelet-activating factor 1-O-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine.

Authors:  F H Valone; B Johnson
Journal:  J Immunol       Date:  1985-02       Impact factor: 5.422

Review 4.  The synthesis, catabolism, and pathophysiological role of platelet-activating factor.

Authors:  A Sturk; J W ten Cate; D Hosford; J M Mencia-Huerta; P Braquet
Journal:  Adv Lipid Res       Date:  1989

5.  Changes of fluorescence anisotropy in plasma membrane of human polymorphonuclear leukocytes during the respiratory burst phenomenon.

Authors:  R Fiorini; G Curatola; E Bertoli; P L Giorgi; A Kantar
Journal:  FEBS Lett       Date:  1990-10-29       Impact factor: 4.124

6.  Effect of cholesterol on membrane microheterogeneity: a study using 1,6-diphenyl-1,3,5-hexatriene fluorescence lifetime distributions.

Authors:  R Fiorini; E Gratton; G Curatola
Journal:  Biochim Biophys Acta       Date:  1989-11-28

7.  Steady state fluorescence polarization and Fourier transform infrared spectroscopy studies on membranes of functionally senescent human erythrocytes.

Authors:  R Fiorini; G Curatola; A Kantar; P L Giorgi; E Bertoli; F Tanfani
Journal:  Biochem Int       Date:  1990

8.  Effect of PAF on erythrocyte membrane heterogeneity: a fluorescence study.

Authors:  A Kantar; P L Giorgi; G Curatola; R Fiorini
Journal:  Agents Actions       Date:  1991-03

Review 9.  Specific receptors of platelet-activating factor, receptor heterogeneity, and signal transduction mechanisms.

Authors:  S B Hwang
Journal:  J Lipid Mediat       Date:  1990 May-Jul

10.  Activation and desensitization of platelets by platelet-activating factor (PAF) derived from IgE-sensitized basophils. I. Characteristics of the secretory response.

Authors:  P M Henson
Journal:  J Exp Med       Date:  1976-04-01       Impact factor: 14.307
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  1 in total

1.  Effect of PAF on human lymphocyte membranes: a fluorescence study.

Authors:  A Kantar; P L Giorgi; R Fiorini
Journal:  Agents Actions       Date:  1993
  1 in total

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