Literature DB >> 1966805

Specific receptors of platelet-activating factor, receptor heterogeneity, and signal transduction mechanisms.

S B Hwang1.   

Abstract

Platelet-activating factor (PAF) exerts its actions through the activation of specific PAF receptors found in a variety of cells and tissues. The signal transduction process induced by PAF appears to be modulated by guanine nucleotide-regulatory proteins (G-proteins) in both rabbit and human platelets and also in human polymorphonuclear leukocytes (PMNs). The PAF receptor, the G-protein coupled to the receptor, and the signal transduction mechanisms in human platelets are different from those in human PMNs. The PAF receptor in human PMNs may also be different from that in human eosinophils. The existence of receptor heterogeneity in guinea pig eosinophils is also proposed. Thus PAF receptor subtypes do exist. Further investigations are required to understand the role of each individual PAF receptor subtype.

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Year:  1990        PMID： 1966805

Source DB:  PubMed          Journal:  J Lipid Mediat        ISSN： 0921-8319


  27 in total

Review 1.  Slit proteins, potential endogenous modulators of inflammation.

Authors:  Necat Havlioglu; Liya Yuan; Hao Tang; Jane Y Wu
Journal:  J Neurovirol       Date:  2002-12       Impact factor: 2.643

2.  Enzymatic digestion of the milk protein beta-casein releases potent chemotactic peptide(s) for monocytes and macrophages.

Authors:  Haruki Kitazawa; Kumiko Yonezawa; Masanori Tohno; Takeshi Shimosato; Yasushi Kawai; Tadao Saito; Ji Ming Wang
Journal:  Int Immunopharmacol       Date:  2007-05-21       Impact factor: 4.932

3.  1-O-hexadecyl-2-acetyl-sn-glycero-3-phospho (N,N,N trimethyl) hexanolamine: an analogue of platelet-activating factor with partial agonist activity.

Authors:  G Grigoriadis; A G Stewart
Journal:  Br J Pharmacol       Date:  1991-09       Impact factor: 8.739

4.  Regulation of platelet-activating factor receptor expression in human B cells and B cell lines.

Authors:  C M Nguer; D Treton; M Rola-Pleszczynski; Z Mishal; Y Thomas; P Galanaud; Y Richard
Journal:  Lipids       Date:  1996-10       Impact factor: 1.880

5.  Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin.

Authors:  H A Gelbard; H S Nottet; S Swindells; M Jett; K A Dzenko; P Genis; R White; L Wang; Y B Choi; D Zhang
Journal:  J Virol       Date:  1994-07       Impact factor: 5.103

6.  Differential antagonism of platelet activating factor-induced neutrophilia and gastric hemorrhage in the rat.

Authors:  T K Thomas; R S Chesonis; D Schmolze; J Symington; M L Harbison; A Walser; P C Will
Journal:  Agents Actions       Date:  1993

7.  Regulation of platelet-activating-factor receptors and the desensitization response in polymorphonuclear neutrophils.

Authors:  J T O'Flaherty; D P Jacobson; J F Redman
Journal:  Biochem J       Date:  1992-11-15       Impact factor: 3.857

8.  Protein tyrosine phosphorylation and regulation of the receptor for platelet-activating factor in rat Kupffer cells. Effect of sodium vanadate.

Authors:  W Chao; H Liu; D J Hanahan; M S Olson
Journal:  Biochem J       Date:  1992-12-15       Impact factor: 3.857

9.  Albumin inhibits platelet-activating factor (PAF)-induced responses in platelets and macrophages: implications for the biologically active form of PAF.

Authors:  G Grigoriadis; A G Stewart
Journal:  Br J Pharmacol       Date:  1992-09       Impact factor: 8.739

10.  Identification and functional characterization of platelet-activating factor receptors in human leukocyte populations using polyclonal anti-peptide antibody.

Authors:  E Müller; P Dagenais; N Alami; M Rola-Pleszczynski
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205
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