Literature DB >> 8317302

Effect of PAF on human lymphocyte membranes: a fluorescence study.

A Kantar1, P L Giorgi, R Fiorini.   

Abstract

We have studied the effect of platelet-activating factor (PAF) on the physico-chemical organization of human lymphocyte plasma membranes by measuring the steady-state fluorescence anisotropy and the fluorescence decay of 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene (TMA-DPH) incorporated in lymphocyte plasma membranes. PAF induced a time-limited and significant increase of the lipid order in the exterior part of the membrane and a decrease in membrane heterogeneity. These changes were blocked in the presence of PAF antagonist L-659,989. The results indicate that the observed changes in the physico-chemical properties of the lymphocyte plasma membranes may be attributed to a PAF-receptor interaction.

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Year:  1993        PMID： 8317302     DOI： 10.1007/bf01991155

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  7 in total

Review 1.  The synthesis, catabolism, and pathophysiological role of platelet-activating factor.

Authors:  A Sturk; J W ten Cate; D Hosford; J M Mencia-Huerta; P Braquet
Journal:  Adv Lipid Res       Date:  1989

2.  Erythrocyte membrane heterogeneity studied using 1,6-diphenyl-1,3,5-hexatriene fluorescence lifetime distribution.

Authors:  R M Fiorini; M Valentino; E Gratton; E Bertoli; G Curatola
Journal:  Biochem Biophys Res Commun       Date:  1987-08-31       Impact factor: 3.575

3.  Changes of fluorescence anisotropy in plasma membrane of human polymorphonuclear leukocytes during the respiratory burst phenomenon.

Authors:  R Fiorini; G Curatola; E Bertoli; P L Giorgi; A Kantar
Journal:  FEBS Lett       Date:  1990-10-29       Impact factor: 4.124

4.  TMA-DPH: a suitable fluorescence polarization probe for specific plasma membrane fluidity studies in intact living cells.

Authors:  J G Kuhry; P Fonteneau; G Duportail; C Maechling; G Laustriat
Journal:  Cell Biophys       Date:  1983-06

5.  Effect of PAF on erythrocyte membrane heterogeneity: a fluorescence study.

Authors:  A Kantar; P L Giorgi; G Curatola; R Fiorini
Journal:  Agents Actions       Date:  1991-03

6.  The metabolism of platelet-activating factor in human T-lymphocytes.

Authors:  J B Travers; H Sprecher; R H Fertel
Journal:  Biochim Biophys Acta       Date:  1990-02-06

7.  Interaction between PAF and human platelet membranes: a fluorescence study.

Authors:  A Kantar; P L Giorgi; G Curatola; R Fiorini
Journal:  Mediators Inflamm       Date:  1992       Impact factor: 4.711
  7 in total
  1 in total

1.  Influence of platelet-activating factor, lyso-platelet-activating factor and edelfosine on Langmuir monolayers imitating plasma membranes of cell lines differing in susceptibility to anti-cancer treatment: the effect of plasmalogen level.

Authors:  Michał Flasiński; Katarzyna Hąc-Wydro; Paweł Wydro; Patrycja Dynarowicz-Łątka
Journal:  J R Soc Interface       Date:  2014-04-02       Impact factor: 4.118
  1 in total

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