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Literature DB >> 1847503

Induction of a cyclic AMP-responsive gene in living cells requires the nuclear factor CREB.

J L Meinkoth¹, M R Montminy, J S Fink, J R Feramisco.

Abstract

We constructed cell lines containing various enhancer elements cloned upstream from a marker gene. By microinjection of specific antibodies directed against transcriptional activator proteins into these cell lines, we have developed a functional assay for factors which regulate the activity of target promoters. Here we show that microinjection of a highly specific antibody to the cyclic AMP enhancer element-binding (CREB) protein diminishes gene expression in response to cyclic AMP in living fibroblasts.

Entities: Chemical Gene

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Year: 1991 PMID： 1847503 PMCID： PMC369493 DOI： 10.1128/mcb.11.3.1759-1764.1991

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

24 in total

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Authors: M Imagawa; R Chiu; M Karin
Journal: Cell Date: 1987-10-23 Impact factor: 41.582

2. Tissue-specific enhancer of the human glycoprotein hormone alpha-subunit gene: dependence on cyclic AMP-inducible elements.

Authors: A M Delegeane; L H Ferland; P L Mellon
Journal: Mol Cell Biol Date: 1987-11 Impact factor: 4.272

3. Identification of factors that interact with the E1A-inducible adenovirus E3 promoter.

Authors: H C Hurst; N C Jones
Journal: Genes Dev Date: 1987-12 Impact factor: 11.361

Review 4. Cyclic AMP response element binding proteins: a cornucopia of transcription factors.

Authors: J F Habener
Journal: Mol Endocrinol Date: 1990-08

5. Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains.

Authors: J M Short; A Wynshaw-Boris; H P Short; R W Hanson
Journal: J Biol Chem Date: 1986-07-25 Impact factor: 5.157

6. Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB.

Authors: K K Yamamoto; G A Gonzalez; W H Biggs; M R Montminy
Journal: Nature Date: 1988-08-11 Impact factor: 49.962

7. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

Authors: P J Southern; P Berg
Journal: J Mol Appl Genet Date: 1982

8. A cyclic AMP- and phorbol ester-inducible DNA element.

Authors: M Comb; N C Birnberg; A Seasholtz; E Herbert; H M Goodman
Journal: Nature Date: 1986 Sep 25-Oct 1 Impact factor: 49.962

9. The gonadotropin alpha-gene contains multiple protein binding domains that interact to modulate basal and cAMP-responsive transcription.

Authors: J L Jameson; R C Jaffe; P J Deutsch; C Albanese; J F Habener
Journal: J Biol Chem Date: 1988-07-15 Impact factor: 5.157

10. Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

Authors: M R Montminy; K A Sevarino; J A Wagner; G Mandel; R H Goodman
Journal: Proc Natl Acad Sci U S A Date: 1986-09 Impact factor: 11.205

15 in total

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Authors: S E Rutberg; Y M Yang; Z Ronai
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Review 2. Signal transduction through the cAMP-dependent protein kinase.

Authors: J L Meinkoth; A S Alberts; W Went; D Fantozzi; S S Taylor; M Hagiwara; M Montminy; J R Feramisco
Journal: Mol Cell Biochem Date: 1993-11 Impact factor: 3.396

3. Lipoteichoic acid isolated from Lactobacillus plantarum inhibits melanogenesis in B16F10 mouse melanoma cells.

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4. The effect of cyclic-AMP on the regulation of c-myc expression in T lymphoma cells.

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Journal: J Clin Invest Date: 1995-04 Impact factor: 14.808

5. The core promoter region of the tumor necrosis factor alpha gene confers phorbol ester responsiveness to upstream transcriptional activators.

Authors: D C Leitman; E R Mackow; T Williams; J D Baxter; B L West
Journal: Mol Cell Biol Date: 1992-03 Impact factor: 4.272

6. Identification of cis- and trans-acting factors regulating the expression of rat salivary-specific RP4 gene.

Authors: H H Lin; D K Ann
Journal: Gene Expr Date: 1992

7. Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements.

Authors: A S Alberts; T Deng; A Lin; J L Meinkoth; A Schönthal; M C Mumby; M Karin; J R Feramisco
Journal: Mol Cell Biol Date: 1993-04 Impact factor: 4.272

8. Cyclic AMP response element-binding protein and the catalytic subunit of protein kinase A are present in F9 embryonal carcinoma cells but are unable to activate the somatostatin promoter.

Authors: N Masson; M Ellis; S Goodbourn; K A Lee
Journal: Mol Cell Biol Date: 1992-03 Impact factor: 4.272

9. Molecular basis for developmental changes in interleukin-2 gene inducibility.

Authors: D Chen; E V Rothenberg
Journal: Mol Cell Biol Date: 1993-01 Impact factor: 4.272

10. A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist.

Authors: J C Yin; J S Wallach; E L Wilder; J Klingensmith; D Dang; N Perrimon; H Zhou; T Tully; W G Quinn
Journal: Mol Cell Biol Date: 1995-09 Impact factor: 4.272