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Literature DB >> 7651429

A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist.

J C Yin¹, J S Wallach, E L Wilder, J Klingensmith, D Dang, N Perrimon, H Zhou, T Tully, W G Quinn.

Abstract

We have characterized a Drosophila gene that is a highly conserved homolog of the mammalian cyclic AMP (cAMP)-responsive transcription factors CREB and CREM. Uniquely among Drosophila genes characterized to date, it codes for a cAMP-responsive transcriptional activator. An alternatively spliced product of the same gene is a specific antagonist of cAMP-inducible transcription. Analysis of the splicing pattern of the gene suggests that the gene may be the predecessor of the mammalian CREB and CREM genes.

Entities: Chemical Gene Species

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Year: 1995 PMID： 7651429 PMCID： PMC230759 DOI： 10.1128/MCB.15.9.5123

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

76 in total

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2. Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein.

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3. C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia.

Authors: C M Alberini; M Ghirardi; R Metz; E R Kandel
Journal: Cell Date: 1994-03-25 Impact factor: 41.582

4. Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion.

Authors: A T Harootunian; S R Adams; W Wen; J L Meinkoth; S S Taylor; R Y Tsien
Journal: Mol Biol Cell Date: 1993-10 Impact factor: 4.138

5. Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors.

Authors: E Hummler; T J Cole; J A Blendy; R Ganss; A Aguzzi; W Schmid; F Beermann; G Schütz
Journal: Proc Natl Acad Sci U S A Date: 1994-06-07 Impact factor: 11.205

6. Drosophila hedgehog acts as a morphogen in cellular patterning.

Authors: J Heemskerk; S DiNardo
Journal: Cell Date: 1994-02-11 Impact factor: 41.582

7. Recombinant cyclic AMP response element binding protein (CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei.

Authors: A S Alberts; J Arias; M Hagiwara; M R Montminy; J R Feramisco
Journal: J Biol Chem Date: 1994-03-11 Impact factor: 5.157

8. Phase shifting of the circadian clock by induction of the Drosophila period protein.

Authors: I Edery; J E Rutila; M Rosbash
Journal: Science Date: 1994-01-14 Impact factor: 47.728

9. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.

Authors: Y Echelard; D J Epstein; B St-Jacques; L Shen; J Mohler; J A McMahon; A P McMahon
Journal: Cell Date: 1993-12-31 Impact factor: 41.582

10. Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript.

Authors: D Masquilier; N S Foulkes; M G Mattei; P Sassone-Corsi
Journal: Cell Growth Differ Date: 1993-11

40 in total

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3. Defective learning in mutants of the Drosophila gene for a regulatory subunit of cAMP-dependent protein kinase.

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4. Expression of heterogeneous nuclear ribonucleoproteins A2 and b1 in the thyroid follicular cells.

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Review 5. Deconstructing memory in Drosophila.

Authors: Carla Margulies; Tim Tully; Josh Dubnau
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Review 6. Conservation of gene function in behaviour.

Authors: Christopher J Reaume; Marla B Sokolowski
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7. The CRE-binding protein dCREB-A is required for Drosophila embryonic development.

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Journal: Genetics Date: 1997-06 Impact factor: 4.562

Review 8. Discovery of genes involved with learning and memory: an experimental synthesis of Hirschian and Benzerian perspectives.

Authors: T Tully
Journal: Proc Natl Acad Sci U S A Date: 1996-11-26 Impact factor: 11.205

Review 9. Transcriptional regulation by cAMP and Ca2+ links the Na+/Ca2+ exchanger 3 to memory and sensory pathways.

Authors: Nadia Gabellini
Journal: Mol Neurobiol Date: 2004-08 Impact factor: 5.590

10. dCREB2-mediated enhancement of memory formation.

Authors: Thomas C Tubon; Jiabin Zhang; Eugenia L Friedman; Haining Jin; Erin D Gonzales; Hong Zhou; Diana Drier; Jason R Gerstner; Emily A Paulson; Robin Fropf; Jerry C P Yin
Journal: J Neurosci Date: 2013-04-24 Impact factor: 6.167