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Literature DB >> 18470725

Acetylcholinesterase in intestinal cell differentiation involves G2/M cell cycle arrest.

Abstract

Here we examine differentiation of the intestinal cell line Caco-2 following exposure to sodium butyrate (NaBT), using alkaline phosphatase (ALP) activity and carcinoembryonic antigen (CEA) levels as markers of differentiation. We show that acetylcholinesterase (AChE) activity and RNA levels increase during differentiation. Treatment with AChE inhibitors or knockdown of AChE levels by shRNA markedly decrease ALP and CEA levels in a concentration- and time-dependent manner. Finally, our observations suggest that NaBT-induced differentiation of intestinal cells involves AChE-induced cell cycle arrest.

Entities: Chemical Disease Gene

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Year: 2008 PMID： 18470725 DOI： 10.1007/s00018-008-8016-3

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

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Acetylcholinesterase in intestinal cell differentiation involves G2/M cell cycle arrest.

1. The efficacy of CT arteriography for spinal arteriovenous fistula surgery: technical note.

2. Preangiographic evaluation of spinal dural arteriovenous fistulas with elliptic centric contrast-enhanced MR Angiography and effect on radiation dose and volume of iodinated contrast material.

3. Embolization of spinal dural arteriovenous fistula with polyvinyl alcohol particles: experience in 14 patients.

4. Breath-hold gadolinium-enhanced MR angiography of the abdominal aorta and its major branches.

5. Constructive interference in steady state-3DFT MR imaging of the inner ear and cerebellopontine angle.

6. Peripheral spinal cord hypointensity on T2-weighted MR images: a reliable imaging sign of venous hypertensive myelopathy.

7. Spinal dural arteriovenous fistula localization with a technique of first-pass gadolinium-enhanced MR angiography: initial experience.

8. Spinal dural arteriovenous fistulas: MR and myelographic findings.

9. Value and limitations of contrast-enhanced MR angiography in spinal arteriovenous malformations and dural arteriovenous fistulas.

1. Quantification of the transcripts encoding different forms of AChE in various cell types: real-time PCR coupled with standards in revealing the copy number.

2. Acetylcholinesterase plays a non-neuronal, non-esterase role in organogenesis.

Review 3. Muscarinic Receptors Associated with Cancer.

Review 4. Deregulated proliferation and differentiation in brain tumors.

Review 5. Role of acetylcholinesterase in lung cancer.

6. Acetylcholinesterase overexpression mediated by oncolytic adenovirus exhibited potent anti-tumor effect.