Literature DB >> 18444258

Tuning of the H-transfer coordinate in primitive versus well-evolved enzymes.

Atsushi Yahashiri1, Elizabeth E Howell, Amnon Kohen.   

Abstract

Mesh：

Substances：

Year:  2008        PMID： 18444258      PMCID： PMC2745209          DOI： 10.1002/cphc.200800067

Source DB:  PubMed          Journal:  Chemphyschem        ISSN： 1439-4235            Impact factor:   3.102


× No keyword cloud information.
  30 in total

Review 1.  Searching sequence space: two different approaches to dihydrofolate reductase catalysis.

Authors:  Elizabeth E Howell
Journal:  Chembiochem       Date:  2005-04       Impact factor: 3.164

2.  Mechanistic studies of R67 dihydrofolate reductase. Effects of pH and an H62C mutation.

Authors:  H Park; P Zhuang; R Nichols; E E Howell
Journal:  J Biol Chem       Date:  1997-01-24       Impact factor: 5.157

3.  Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.

Authors:  M R Sawaya; J Kraut
Journal:  Biochemistry       Date:  1997-01-21       Impact factor: 3.162

4.  The purification and properties of the trimethoprim-resistant dihydrofolate reductase mediated by the R-factor, R388.

Authors:  S G Amyes; J T Smith
Journal:  Eur J Biochem       Date:  1976-01-15

5.  Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase.

Authors:  A Kohen; R Cannio; S Bartolucci; J P Klinman
Journal:  Nature       Date:  1999-06-03       Impact factor: 49.962

6.  A glutamine 67--> histidine mutation in homotetrameric R67 dihydrofolate reductase results in four mutations per single active site pore and causes substantial substrate and cofactor inhibition.

Authors:  H Park; T D Bradrick; E E Howell
Journal:  Protein Eng       Date:  1997-12

7.  Combinatorial exploration of the catalytic site of a drug-resistant dihydrofolate reductase: creating alternative functional configurations.

Authors:  Andreea R Schmitzer; François Lépine; Joelle N Pelletier
Journal:  Protein Eng Des Sel       Date:  2004-12-02       Impact factor: 1.650

8.  NMR studies of the interaction of a type II dihydrofolate reductase with pyridine nucleotides reveal unexpected phosphatase and reductase activity.

Authors:  Wayne H Pitcher; Eugene F DeRose; Geoffrey A Mueller; Elizabeth E Howell; Robert E London
Journal:  Biochemistry       Date:  2003-09-30       Impact factor: 3.162

9.  Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues.

Authors:  S R Stone; J F Morrison
Journal:  Biochim Biophys Acta       Date:  1986-02-14

10.  Breaking symmetry: mutations engineered into R67 dihydrofolate reductase, a D2 symmetric homotetramer possessing a single active site pore.

Authors:  R Derike Smiley; Lori G Stinnett; Arnold M Saxton; Elizabeth E Howell
Journal:  Biochemistry       Date:  2002-12-31       Impact factor: 3.162
View more
  13 in total

1.  Characterizing the dynamics of functionally relevant complexes of formate dehydrogenase.

Authors:  Jigar N Bandaria; Samrat Dutta; Michael W Nydegger; William Rock; Amnon Kohen; Christopher M Cheatum
Journal:  Proc Natl Acad Sci U S A       Date:  2010-09-27       Impact factor: 11.205

2.  Triple isotopic labeling and kinetic isotope effects: exposing H-transfer steps in enzymatic systems.

Authors:  Arundhuti Sen; Atsushi Yahashiri; Amnon Kohen
Journal:  Biochemistry       Date:  2011-06-30       Impact factor: 3.162

3.  Microscale synthesis and kinetic isotope effect analysis of (4R)-[Ad-14C, 4-2H] NADPH and (4R)-[Ad-3H,4-2H] NADPH.

Authors:  Atsushi Yahashiri; Arundhuti Sen; Amnon Kohen
Journal:  J Labelled Comp Radiopharm       Date:  2009-09-15       Impact factor: 1.921

4.  Protein dynamics and enzymatic chemical barrier passage.

Authors:  Dimitri Antoniou; Steven D Schwartz
Journal:  J Phys Chem B       Date:  2011-11-15       Impact factor: 2.991

5.  A twin-track approach has optimized proton and hydride transfer by dynamically coupled tunneling during the evolution of protochlorophyllide oxidoreductase.

Authors:  Derren J Heyes; Colin Levy; Michiyo Sakuma; David L Robertson; Nigel S Scrutton
Journal:  J Biol Chem       Date:  2011-02-11       Impact factor: 5.157

6.  Hydrogen tunneling in adenosylcobalamin-dependent glutamate mutase: evidence from intrinsic kinetic isotope effects measured by intramolecular competition.

Authors:  Miri Yoon; Hangtian Song; Kristina Håkansson; E Neil G Marsh
Journal:  Biochemistry       Date:  2010-04-13       Impact factor: 3.162

7.  Update 1 of: Tunneling and dynamics in enzymatic hydride transfer.

Authors:  Zachary D Nagel; Judith P Klinman
Journal:  Chem Rev       Date:  2010-12-08       Impact factor: 60.622

8.  The effect of electrostatic shielding on H tunneling in R67 dihydrofolate reductase.

Authors:  Atsushi Yahashiri; Guy Nimrod; Nir Ben-Tal; Elizabeth E Howell; Amnon Kohen
Journal:  Chembiochem       Date:  2009-11-02       Impact factor: 3.164

9.  Examination of enzymatic H-tunneling through kinetics and dynamics.

Authors:  Jigar N Bandaria; Christopher M Cheatum; Amnon Kohen
Journal:  J Am Chem Soc       Date:  2009-07-29       Impact factor: 15.419

10.  Role of long-range protein dynamics in different thymidylate synthase catalyzed reactions.

Authors:  Thelma Abeysinghe; Amnon Kohen
Journal:  Int J Mol Sci       Date:  2015-04-01       Impact factor: 5.923
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.