J Draxler1, M Schuch, A Paul, T Sycha, C Valenta, R Likar, B Gustorff. 1. Universitätsklinik für Anästhesie, Allgemeine Intensivmedizin und Schmerztherapie, Medizinische Universität Wien, Währinger Gürtel 18-20, A-1090 Wien, Osterreich.
Abstract
BACKGROUND: The aim of this placebo-controlled double-blinded cross-over study was to investigate the antihyperalgesic effect of topical morphine and buprenorphine in the sunburn pain model. MATERIAL AND METHODS: The study was designed as a double-blind, placebo-controlled cross-over trial, separated into 2 parts each with 16 volunteers. In part A morphine dissolved in Ultrabas-ultrasic ointment at 3 concentrations (0.1, 0.2, 0.4%) and placebo ointment were applied to 4 UVB-induced erythemas on the thighs. In part B buprenorphine at 3 concentrations (0.01, 0.02 and 0.1%) and placebo dissolved in a gel for transcutaneous application, was applied to 4 erythemas on the thighs. Thermal and mechanical hyperalgesia were assessed in the respective erythema by standardized quantitative sensory testing and opioids were compared to the placebo. RESULTS: Neither morphine nor buprenorphine showed any significant reduction of hyperalgesia in comparison to the placebo. CONCLUSION: The topical application of opioids in this form has no effect on inflamed skin.
RCT Entities:
BACKGROUND: The aim of this placebo-controlled double-blinded cross-over study was to investigate the antihyperalgesic effect of topical morphine and buprenorphine in the sunburn pain model. MATERIAL AND METHODS: The study was designed as a double-blind, placebo-controlled cross-over trial, separated into 2 parts each with 16 volunteers. In part A morphine dissolved in Ultrabas-ultrasic ointment at 3 concentrations (0.1, 0.2, 0.4%) and placebo ointment were applied to 4 UVB-induced erythemas on the thighs. In part B buprenorphine at 3 concentrations (0.01, 0.02 and 0.1%) and placebo dissolved in a gel for transcutaneous application, was applied to 4 erythemas on the thighs. Thermal and mechanical hyperalgesia were assessed in the respective erythema by standardized quantitative sensory testing and opioids were compared to the placebo. RESULTS: Neither morphine nor buprenorphine showed any significant reduction of hyperalgesia in comparison to the placebo. CONCLUSION: The topical application of opioids in this form has no effect on inflamed skin.
Authors: Thomas Sycha; Sebastian Anzenhofer; Stephan Lehr; Leopold Schmetterer; Boris Chizh; Hans-Georg Eichler; Burkhard Gustorff Journal: Pain Date: 2005-02 Impact factor: 6.961