AIM: The aim of this study was to demonstrate a peripheral local opioid effect using case examples involving inflammatory mucosal and cutaneous lesions. METHODS: A 0.1% morphine gel, mixed in the hospital pharmacy, was applied several times daily to inflammatory mucosal lesions (oral, anogenital and in one patient to a skin ulcer). The effects and side effects were documented. RESULT: All patients experienced a significant reduction in pain with the use of topical morphine gel and no side effects were seen. CONCLUSION: Topical peripheral application of morphine gel is a simple, effective method that can be carried out by patients several times a day with few side effects.
AIM: The aim of this study was to demonstrate a peripheral local opioid effect using case examples involving inflammatory mucosal and cutaneous lesions. METHODS: A 0.1% morphine gel, mixed in the hospital pharmacy, was applied several times daily to inflammatory mucosal lesions (oral, anogenital and in one patient to a skin ulcer). The effects and side effects were documented. RESULT: All patients experienced a significant reduction in pain with the use of topical morphine gel and no side effects were seen. CONCLUSION: Topical peripheral application of morphine gel is a simple, effective method that can be carried out by patients several times a day with few side effects.
Authors: Leandro C A Cerchietti; Alfredo H Navigante; Marcelo R Bonomi; Mariel A Zaderajko; Pablo R Menéndez; Catalina E Pogany; Berta M C Roth Journal: Cancer Date: 2002-11-15 Impact factor: 6.860