| Literature DB >> 12894165 |
Christoph Stein1, Michael Schäfer, Halina Machelska.
Abstract
The treatment of severe pain with opioids has thus far been limited by their unwanted central side effects. Recent research promises new approaches, including opioid analgesics acting outside the central nervous system, targeting of opioid peptide-containing immune cells to peripheral damaged tissue, and gene transfer to enhance opioid production at sites of injury.Entities:
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Year: 2003 PMID： 12894165 DOI： 10.1038/nm908
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440