OBJECTIVE: In order to prospectively investigate physical activity at varying intensities and sedentary behavior in relation to colorectal cancer. METHODS: We considered 488,720 participants of the NIH-AARP Diet and Health Study who were aged 50-71 years at baseline in 1995-1996. Through 31 December, 2003, we identified 3,240 and 1,482 colorectal cancers among men and women, respectively. We estimated multivariable relative risks (RR) and 95% confidence intervals (CI) of colorectal cancer using Cox regression. RESULTS: Engaging in exercise/sports five or more times per week compared to never or rarely exercising was associated with a reduced risk of colon cancer among men (p = 0.001; RR = 0.79, 95% CI = 0.68-0.91) and a suggestive decrease in risk among women (p = 0.376; RR = 0.85, 95% CI = 0.70-1.04). Engaging in exercise/sports was also associated with a decreased risk of rectal cancer in men (P = 0.074; RR comparing extreme categories = 0.76, 95% CI = 0.61-0.94). In men, we observed inverse relations of both low intensity (p = 0.017; RR = 0.81, 95% CI = 0.65-1.00 for > or =7 h/week) and moderate to vigorous intensity activity (p = 0.037; RR = 0.82, 95% CI = 0.67-0.99 for > or =7 h/week) to colon cancer risk. In contrast, sedentary behavior (time spent watching television/videos) was positively associated with colon cancer (p < 0.001; RR = 1.61, 95% CI = 1.14-2.27 for > or =9 h/day) among men. Similar, but less pronounced relations were observed in women. CONCLUSION: Engaging in physical activity of any intensity is associated with reductions in colon and rectal cancer risk. Conversely, time spent sedentary is associated with increased colon cancer risk.
OBJECTIVE: In order to prospectively investigate physical activity at varying intensities and sedentary behavior in relation to colorectal cancer. METHODS: We considered 488,720 participants of the NIH-AARP Diet and Health Study who were aged 50-71 years at baseline in 1995-1996. Through 31 December, 2003, we identified 3,240 and 1,482 colorectal cancers among men and women, respectively. We estimated multivariable relative risks (RR) and 95% confidence intervals (CI) of colorectal cancer using Cox regression. RESULTS: Engaging in exercise/sports five or more times per week compared to never or rarely exercising was associated with a reduced risk of colon cancer among men (p = 0.001; RR = 0.79, 95% CI = 0.68-0.91) and a suggestive decrease in risk among women (p = 0.376; RR = 0.85, 95% CI = 0.70-1.04). Engaging in exercise/sports was also associated with a decreased risk of rectal cancer in men (P = 0.074; RR comparing extreme categories = 0.76, 95% CI = 0.61-0.94). In men, we observed inverse relations of both low intensity (p = 0.017; RR = 0.81, 95% CI = 0.65-1.00 for > or =7 h/week) and moderate to vigorous intensity activity (p = 0.037; RR = 0.82, 95% CI = 0.67-0.99 for > or =7 h/week) to colon cancer risk. In contrast, sedentary behavior (time spent watching television/videos) was positively associated with colon cancer (p < 0.001; RR = 1.61, 95% CI = 1.14-2.27 for > or =9 h/day) among men. Similar, but less pronounced relations were observed in women. CONCLUSION: Engaging in physical activity of any intensity is associated with reductions in colon and rectal cancer risk. Conversely, time spent sedentary is associated with increased colon cancer risk.
Authors: A S Whittemore; A H Wu-Williams; M Lee; S Zheng; R P Gallagher; D A Jiao; L Zhou; X H Wang; K Chen; D Jung Journal: J Natl Cancer Inst Date: 1990-06-06 Impact factor: 13.506
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Authors: R Ballard-Barbash; A Schatzkin; D Albanes; M H Schiffman; B E Kreger; W B Kannel; K M Anderson; W E Helsel Journal: Cancer Res Date: 1990-06-15 Impact factor: 12.701
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Authors: A Tavani; C Braga; C La Vecchia; E Conti; R Filiberti; M Montella; D Amadori; A Russo; S Franceschi Journal: Br J Cancer Date: 1999-04 Impact factor: 7.640
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