| Literature DB >> 18426196 |
Brian K Albrecht1, Jean-Christophe Harmange, David Bauer, Loren Berry, Christiane Bode, Alessandro A Boezio, April Chen, Deborah Choquette, Isabelle Dussault, Cary Fridrich, Satoko Hirai, Doug Hoffman, Jay F Larrow, Paula Kaplan-Lefko, Jasmine Lin, Julia Lohman, Alexander M Long, Jodi Moriguchi, Anne O'Connor, Michele H Potashman, Monica Reese, Karen Rex, Aaron Siegmund, Kavita Shah, Roman Shimanovich, Stephanie K Springer, Yohannes Teffera, Yajing Yang, Yihong Zhang, Steven F Bellon.
Abstract
Tumorigenesis is a multistep process in which oncogenes play a key role in tumor formation, growth, and maintenance. MET was discovered as an oncogene that is activated by its ligand, hepatocyte growth factor. Deregulated signaling in the c-Met pathway has been observed in multiple tumor types. Herein we report the discovery of potent and selective triazolopyridazine small molecules that inhibit c-Met activity.Entities:
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Year: 2008 PMID： 18426196 DOI： 10.1021/jm800043g
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446