OBJECTIVE: Transcranial Duplex ultrasound imaging with ultrasound contrast agents is an emerging technique for evaluating brain perfusion. The aim of this study was to evaluate cerebral perfusion with ultrasound in brain space-occupying lesions to identify different perfusion patterns. METHODS: Twenty patients with brain space-occupying lesions underwent ultrasound assessment of brain perfusion with a contrast pulse sequencing nonharmonic ultrasound technique and an ultrasound contrast agent bolus. Data were analyzed with software for semiquantitative analysis. RESULTS: Contrast pulse sequencing imaging with the semiquantitative analysis software allowed identification of qualitative and semiquantitative brain perfusion. Brain hemorrhages showed lower or absent perfusion compared with normal tissue. Meningiomas and glioblastomas without large necrotic areas showed higher perfusion compared with normal tissue. Glioblastomas with large necrotic areas showed overall reduced perfusion compared with normal tissue but higher than that of brain hemorrhages. In glioblastomas with large necrotic areas, it was possible to distinguish between solid and necrotic tissue. CONCLUSIONS: This bedside ultrasound technique, if validated by larger-scale studies, may add helpful information in noninvasive staging of brain tumors. Further potential applications may be in follow-up imaging to evaluate postoperative tumor recurrence or the presence of radionecrosis.
OBJECTIVE: Transcranial Duplex ultrasound imaging with ultrasound contrast agents is an emerging technique for evaluating brain perfusion. The aim of this study was to evaluate cerebral perfusion with ultrasound in brain space-occupying lesions to identify different perfusion patterns. METHODS: Twenty patients with brain space-occupying lesions underwent ultrasound assessment of brain perfusion with a contrast pulse sequencing nonharmonic ultrasound technique and an ultrasound contrast agent bolus. Data were analyzed with software for semiquantitative analysis. RESULTS: Contrast pulse sequencing imaging with the semiquantitative analysis software allowed identification of qualitative and semiquantitative brain perfusion. Brain hemorrhages showed lower or absent perfusion compared with normal tissue. Meningiomas and glioblastomas without large necrotic areas showed higher perfusion compared with normal tissue. Glioblastomas with large necrotic areas showed overall reduced perfusion compared with normal tissue but higher than that of brain hemorrhages. In glioblastomas with large necrotic areas, it was possible to distinguish between solid and necrotic tissue. CONCLUSIONS: This bedside ultrasound technique, if validated by larger-scale studies, may add helpful information in noninvasive staging of brain tumors. Further potential applications may be in follow-up imaging to evaluate postoperative tumor recurrence or the presence of radionecrosis.
Authors: Ilya Lekht; Noah Brauner; Joshua Bakhsheshian; Ki-Eun Chang; Mittul Gulati; Mark S Shiroishi; Edward G Grant; Eisha Christian; Gabriel Zada Journal: Neurosurg Focus Date: 2016-03 Impact factor: 4.047
Authors: Francesco Prada; Antonio G Gennari; Ian M Linville; Michael E Mutersbaugh; Zhihang Chen; Natasha Sheybani; Francesco DiMeco; Frederic Padilla; John A Hossack Journal: Sci Rep Date: 2021-06-03 Impact factor: 4.379
Authors: Francesco Prada; Luca Mattei; Massimiliano Del Bene; Luca Aiani; Marco Saini; Cecilia Casali; Assunta Filippini; Federico Giuseppe Legnani; Alessandro Perin; Andrea Saladino; Ignazio Gaspare Vetrano; Luigi Solbiati; Alberto Martegani; Francesco DiMeco Journal: Biomed Res Int Date: 2014-06-12 Impact factor: 3.411