BACKGROUND AND OBJECTIVES: The increasing rates of resistance exhibited by uropathogens represent a serious problem. The aim of this study was to determine, in Spain, the etiology of community-acquired lower urinary infections and antimicrobial resistance of Escherichia coli isolates. METHODS: Prospective multicenter study conducted between February and June 2006, in 15 microbiology laboratories located in 9 autonomous regions. RESULTS: A total of 3,109 isolates were recovered. E. coli was the most frequent (70.8%), followed by Klebsiella spp (6.8%) Proteus spp (6.6%), and Enterococcus spp (5.5%). The resistant rate of E. coli for phosphomycin was 1.7%, 3.8% nitrofurantoin, 6.9% cefexime, 8.1% amoxicillin-clavulanic, 8.9% cefuroxime, and 23.9% ciprofloxacin. The 5.2% were extended-spectrum beta-lactamase (ESBL)- producing microorganisms. Resistance of E. coli to ciprofloxacin was lower in people younger than 40 years (6.7% vs 33.9% in > 60, p < 0.001), and in some regions (12.5% in Galicia vs 37.3% in Valencia). ESBL-producing E.coli was higher in people older than 60 years (79.1% vs 7% in < 40, p < 0.001), and exhibited geographic variations (18.4% in Valencia, 0.8% in Galicia). The 68.6% of ESBL-producing E.coli were resistant to cotrimoxazole, 72.2% to ciprofloxacin vs 10.6% to nitrofurantoin and 1.9% to phosphomycin. CONCLUSIONS: The increasing rates of resistance and cross-resistance of this study make evident a real problem that strengthens the need for a reevaluation of the empiric treatment of lower urinary infections.
BACKGROUND AND OBJECTIVES: The increasing rates of resistance exhibited by uropathogens represent a serious problem. The aim of this study was to determine, in Spain, the etiology of community-acquired lower urinary infections and antimicrobial resistance of Escherichia coli isolates. METHODS: Prospective multicenter study conducted between February and June 2006, in 15 microbiology laboratories located in 9 autonomous regions. RESULTS: A total of 3,109 isolates were recovered. E. coli was the most frequent (70.8%), followed by Klebsiella spp (6.8%) Proteus spp (6.6%), and Enterococcus spp (5.5%). The resistant rate of E. coli for phosphomycin was 1.7%, 3.8% nitrofurantoin, 6.9% cefexime, 8.1% amoxicillin-clavulanic, 8.9% cefuroxime, and 23.9% ciprofloxacin. The 5.2% were extended-spectrum beta-lactamase (ESBL)- producing microorganisms. Resistance of E. coli to ciprofloxacin was lower in people younger than 40 years (6.7% vs 33.9% in > 60, p < 0.001), and in some regions (12.5% in Galicia vs 37.3% in Valencia). ESBL-producing E.coli was higher in people older than 60 years (79.1% vs 7% in < 40, p < 0.001), and exhibited geographic variations (18.4% in Valencia, 0.8% in Galicia). The 68.6% of ESBL-producing E.coli were resistant to cotrimoxazole, 72.2% to ciprofloxacin vs 10.6% to nitrofurantoin and 1.9% to phosphomycin. CONCLUSIONS: The increasing rates of resistance and cross-resistance of this study make evident a real problem that strengthens the need for a reevaluation of the empiric treatment of lower urinary infections.
Authors: Phuong Thi Lan Nguyen; Hung Thi Mai Tran; Hai Anh Tran; Thai Duy Pham; Tan Minh Luong; Thanh Ha Nguyen; Lien Thi Phuong Nguyen; Tho Thi Thi Nguyen; Ha Thi An Hoang; Chi Nguyen; Duong Nhu Tran; Anh Duc Dang; Masato Suzuki; Thanh Viet Le; Anne-Laure Bañuls; Marc Choisy; Rogier H Van Doorn; Huy Hoang Tran Journal: Am J Trop Med Hyg Date: 2022-06-13 Impact factor: 3.707
Authors: María F Lorenzo Gómez; Rafael E Collazos Robles; Álvaro J Virseda Rodríguez; María B García Cenador; José A Mirón Canelo; Bárbara Padilla Fernández Journal: Ther Adv Urol Date: 2015-08
Authors: M F Lorenzo-Gómez; B Padilla-Fernández; F J García-Criado; J A Mirón-Canelo; A Gil-Vicente; A Nieto-Huertos; J M Silva-Abuin Journal: Int Urogynecol J Date: 2012-07-18 Impact factor: 2.894
Authors: María F Lorenzo-Gómez; Bárbara Padilla-Fernández; María B García-Cenador; Álvaro J Virseda-Rodríguez; Isidoro Martín-García; Alfonso Sánchez-Escudero; Manuel J Vicente-Arroyo; José A Mirón-Canelo Journal: Front Cell Infect Microbiol Date: 2015-06-03 Impact factor: 5.293