Literature DB >> 18397381

Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol.

D Kapfhamer1, J C Bettinger, A G Davies, C L Eastman, E A Smail, U Heberlein, S L McIntire.   

Abstract

The mechanisms by which ethanol induces changes in behavior are not well understood. Here, we show that Caenorhabditis elegans loss-of-function mutations in the synaptic vesicle-associated RAB-3 protein and its guanosine triphosphate exchange factor AEX-3 confer resistance to the acute locomotor effects of ethanol. Similarly, mice lacking one or both copies of Rab3A are resistant to the ataxic and sedative effects of ethanol, and Rab3A haploinsufficiency increases voluntary ethanol consumption. These data suggest a conserved role of RAB-3-/RAB3A-regulated neurotransmitter release in ethanol-related behaviors.

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Year:  2008        PMID： 18397381      PMCID： PMC3526002          DOI： 10.1111/j.1601-183X.2008.00404.x

Source DB:  PubMed          Journal:  Genes Brain Behav        ISSN： 1601-183X            Impact factor:   3.449


  47 in total

1.  Increased GABA release in the central amygdala of ethanol-dependent rats.

Authors:  Marisa Roberto; Samuel G Madamba; David G Stouffer; Loren H Parsons; George Robert Siggins
Journal:  J Neurosci       Date:  2004-11-10       Impact factor: 6.167

2.  Predictors of high ethanol consumption in RIIbeta knock-out mice: assessment of anxiety and ethanol-induced sedation.

Authors:  Jon R Fee; Dennis R Sparta; Darin J Knapp; George R Breese; Mitchell J Picker; Todd E Thiele
Journal:  Alcohol Clin Exp Res       Date:  2004-10       Impact factor: 3.455

3.  Real-time imaging of Rab3a and Rab5a reveals differential roles in presynaptic function.

Authors:  Erin N Star; A Jamila Newton; Venkatesh N Murthy
Journal:  J Physiol       Date:  2005-09-01       Impact factor: 5.182

4.  Ethanol-induced alterations in Rab proteins: possible implications for pituitary dysfunction.

Authors:  Jian-Ching Ren; Qianlong Zhu; Nancy Lapaglia; Nicholas V Emanuele; Mary Ann Emanuele
Journal:  Alcohol       Date:  2005-02       Impact factor: 2.405

5.  Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity.

Authors:  Oliver M Schlüter; Jayeeta Basu; Thomas C Südhof; Christian Rosenmund
Journal:  J Neurosci       Date:  2006-01-25       Impact factor: 6.167

6.  Ethanol perturbs the secretory pathway in astrocytes.

Authors:  Mónica Tomás; Pilar Marín; Luís Megías; Gustavo Egea; Jaime Renau-Piqueras
Journal:  Neurobiol Dis       Date:  2005-06-13       Impact factor: 5.996

Review 7.  Genetic pharmacology: interactions between drugs and gene products in Caenorhabditis elegans.

Authors:  J B Rand; C D Johnson
Journal:  Methods Cell Biol       Date:  1995       Impact factor: 1.441

8.  The slowpoke gene is necessary for rapid ethanol tolerance in Drosophila.

Authors:  R B Cowmeadow; H R Krishnan; N S Atkinson
Journal:  Alcohol Clin Exp Res       Date:  2005-10       Impact factor: 3.455

9.  Corticotropin-releasing factor overexpression decreases ethanol drinking and increases sensitivity to the sedative effects of ethanol.

Authors:  Abraham A Palmer; Amanda L Sharpe; Sue Burkhart-Kasch; Carrie S McKinnon; Sarah C Coste; Mary P Stenzel-Poore; Tamara J Phillips
Journal:  Psychopharmacology (Berl)       Date:  2004-05-11       Impact factor: 4.530

10.  Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway.

Authors:  M S Moore; J DeZazzo; A Y Luk; T Tully; C M Singh; U Heberlein
Journal:  Cell       Date:  1998-06-12       Impact factor: 41.582
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  37 in total

Review 1.  Cross-species molecular dissection across alcohol behavioral domains.

Authors:  Sean P Farris; Brien P Riley; Robert W Williams; Megan K Mulligan; Michael F Miles; Marcelo F Lopez; Robert Hitzemann; Ovidiu D Iancu; Alexander Colville; Nicole A R Walter; Priscila Darakjian; Denesa L Oberbeck; James B Daunais; Christina L Zheng; Robert P Searles; Shannon K McWeeney; Kathleen A Grant; R Dayne Mayfield
Journal:  Alcohol       Date:  2017-12-06       Impact factor: 2.405

2.  An Assay for Measuring the Effects of Ethanol on the Locomotion Speed of Caenorhabditis elegans.

Authors:  Andrew G Davies; GinaMari G Blackwell; Richard C Raabe; Jill C Bettinger
Journal:  J Vis Exp       Date:  2015-04-09       Impact factor: 1.355

Review 3.  Genes and Alcohol Consumption: Studies with Mutant Mice.

Authors:  J Mayfield; M A Arends; R A Harris; Y A Blednov
Journal:  Int Rev Neurobiol       Date:  2016       Impact factor: 3.230

Review 4.  Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder.

Authors:  Mike Grotewiel; Jill C Bettinger
Journal:  Alcohol Clin Exp Res       Date:  2015-07-14       Impact factor: 3.455

5.  Effect of chronic ethanol treatment on μ-opioid receptor function, interacting proteins and morphine-induced place preference.

Authors:  Masahiro Shibasaki; Kenjiro Watanabe; Kotaro Takeda; Toshimasa Itoh; Tomohisa Tsuyuki; Minoru Narita; Tomohisa Mori; Tsutomu Suzuki
Journal:  Psychopharmacology (Berl)       Date:  2013-02-22       Impact factor: 4.530

6.  Different genes influence toluene- and ethanol-induced locomotor impairment in C. elegans.

Authors:  Andrew G Davies; Ryan I Friedberg; Hersh Gupta; Chung-Lung Chan; Keith L Shelton; Jill C Bettinger
Journal:  Drug Alcohol Depend       Date:  2011-09-25       Impact factor: 4.492

7.  A novel cholinergic action of alcohol and the development of tolerance to that effect in Caenorhabditis elegans.

Authors:  Edward G Hawkins; Ian Martin; Lindsay M Kondo; Meredith E Judy; Victoria E Brings; Chung-Lung Chan; GinaMari G Blackwell; Jill C Bettinger; Andrew G Davies
Journal:  Genetics       Date:  2014-10-23       Impact factor: 4.562

8.  A differential role for neuropeptides in acute and chronic adaptive responses to alcohol: behavioural and genetic analysis in Caenorhabditis elegans.

Authors:  Philippa Mitchell; Richard Mould; James Dillon; Steven Glautier; Ioannis Andrianakis; Christopher James; Amanda Pugh; Lindy Holden-Dye; Vincent O'Connor
Journal:  PLoS One       Date:  2010-05-03       Impact factor: 3.240

9.  Taok2 controls behavioral response to ethanol in mice.

Authors:  D Kapfhamer; S Taylor; M E Zou; J P Lim; V Kharazia; U Heberlein
Journal:  Genes Brain Behav       Date:  2012-08-31       Impact factor: 3.449

10.  Conserved single residue in the BK potassium channel required for activation by alcohol and intoxication in C. elegans.

Authors:  Scott J Davis; Luisa L Scott; Kevin Hu; Jonathan T Pierce-Shimomura
Journal:  J Neurosci       Date:  2014-07-16       Impact factor: 6.167
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