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Literature DB >> 18376415

Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes.

Qing Huai¹, Aiwu Zhou, Lin Lin, Andrew P Mazar, Graham C Parry, Jennifer Callahan, David E Shaw, Bruce Furie, Barbara C Furie, Mingdong Huang.

Abstract

The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor. These results provide a structural understanding of one receptor binding to two ligands.

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Year: 2008 PMID： 18376415 PMCID： PMC2443823 DOI： 10.1038/nsmb.1404

Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369

10 in total

1. Urokinase regulates vitronectin binding by controlling urokinase receptor oligomerization.

Authors: Nicolai Sidenius; Annapaola Andolfo; Riccardo Fesce; Francesco Blasi
Journal: J Biol Chem Date: 2002-05-28 Impact factor: 5.157

Review 2. uPAR: a versatile signalling orchestrator.

Authors: Francesco Blasi; Peter Carmeliet
Journal: Nat Rev Mol Cell Biol Date: 2002-12 Impact factor: 94.444

3. Structure of human urokinase plasminogen activator in complex with its receptor.

Authors: Qing Huai; Andrew P Mazar; Alice Kuo; Graham C Parry; David E Shaw; Jennifer Callahan; Yongdong Li; Cai Yuan; Chuanbing Bian; Liqing Chen; Bruce Furie; Barbara C Furie; Douglas B Cines; Mingdong Huang
Journal: Science Date: 2006-02-03 Impact factor: 47.728

Review 4. Does the urokinase receptor exist in a latent form?

Authors: C Yuan; M Huang
Journal: Cell Mol Life Sci Date: 2007-05 Impact factor: 9.261

5. Identification of the urokinase receptor as an adhesion receptor for vitronectin.

Authors: Y Wei; D A Waltz; N Rao; R J Drummond; S Rosenberg; H A Chapman
Journal: J Biol Chem Date: 1994-12-23 Impact factor: 5.157

6. Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide.

Authors: Paola Llinas; Marie Hélène Le Du; Henrik Gårdsvoll; Keld Danø; Michael Ploug; Bernard Gilquin; Enrico A Stura; André Ménez
Journal: EMBO J Date: 2005-04-07 Impact factor: 11.598

7. Mapping of the vitronectin-binding site on the urokinase receptor: involvement of a coherent receptor interface consisting of residues from both domain I and the flanking interdomain linker region.

Authors: Henrik Gårdsvoll; Michael Ploug
Journal: J Biol Chem Date: 2007-03-13 Impact factor: 5.157

8. Structural and functional analysis of the plasminogen activator inhibitor-1 binding motif in the somatomedin B domain of vitronectin.

Authors: G Deng; G Royle; S Wang; K Crain; D J Loskutoff
Journal: J Biol Chem Date: 1996-05-31 Impact factor: 5.157

9. How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration.

Authors: Aiwu Zhou; James A Huntington; Navraj S Pannu; Robin W Carrell; Randy J Read
Journal: Nat Struct Biol Date: 2003-07

10. uPAR-induced cell adhesion and migration: vitronectin provides the key.

Authors: Chris D Madsen; Gian Maria Sarra Ferraris; Annapaola Andolfo; Orla Cunningham; Nicolai Sidenius
Journal: J Cell Biol Date: 2007-06-04 Impact factor: 10.539

10 in total

50 in total

1. An anti-urokinase plasminogen activator receptor antibody (ATN-658) blocks prostate cancer invasion, migration, growth, and experimental skeletal metastasis in vitro and in vivo.

Authors: Shafaat A Rabbani; Bushra Ateeq; Ani Arakelian; Maria Luisa Valentino; David E Shaw; Lisa M Dauffenbach; Christopher A Kerfoot; Andrew P Mazar
Journal: Neoplasia Date: 2010-10 Impact factor: 5.715

2. A cleavage-resistant urokinase plasminogen activator receptor exhibits dysregulated cell-surface clearance.

Authors: Evelyn C Nieves; Naveen Manchanda
Journal: J Biol Chem Date: 2010-02-22 Impact factor: 5.157

3. Ab initio molecular simulations for proposing novel peptide inhibitors blocking the ligand-binding pocket of urokinase receptor.

Authors: Tatsuroh Mizushima; Takuya Sugimoto; Tomoyo Kasumi; Kohta Araki; Hiroshi Kobayashi; Noriyuki Kurita
Journal: J Mol Model Date: 2014-05-25 Impact factor: 1.810

4. D2A sequence of the urokinase receptor induces cell growth through αvβ3 integrin and EGFR.

Authors: Gabriele Eden; Marco Archinti; Ralitsa Arnaudova; Giuseppina Andreotti; Andrea Motta; Federico Furlan; Valentina Citro; Maria Vittoria Cubellis; Bernard Degryse
Journal: Cell Mol Life Sci Date: 2017-11-28 Impact factor: 9.261

5. Did evolution create a flexible ligand-binding cavity in the urokinase receptor through deletion of a plesiotypic disulfide bond?

Authors: Julie M Leth; Haydyn D T Mertens; Katrine Zinck Leth-Espensen; Thomas J D Jørgensen; Michael Ploug
Journal: J Biol Chem Date: 2019-03-20 Impact factor: 5.157

6. Small Molecules Engage Hot Spots through Cooperative Binding To Inhibit a Tight Protein-Protein Interaction.

Authors: Degang Liu; David Xu; Min Liu; William Eric Knabe; Cai Yuan; Donghui Zhou; Mingdong Huang; Samy O Meroueh
Journal: Biochemistry Date: 2017-03-17 Impact factor: 3.162

7. Probing binding and cellular activity of pyrrolidinone and piperidinone small molecules targeting the urokinase receptor.

Authors: Timmy Mani; Degang Liu; Donghui Zhou; Liwei Li; William Eric Knabe; Fang Wang; Kyungsoo Oh; Samy O Meroueh
Journal: ChemMedChem Date: 2013-10-02 Impact factor: 3.466