Literature DB >> 12461559

uPAR: a versatile signalling orchestrator.

Francesco Blasi1, Peter Carmeliet.   

Abstract

The plasminogen system has been implicated in clot lysis, wound healing, tissue regeneration, cancer and many other processes that affect health and disease. The urokinase receptor uPAR was originally thought to assist the directional invasion of migrating cells, but it is now becoming increasingly evident that this proteinase receptor elicits a plethora of cellular responses that include cellular adhesion, differentiation, proliferation and migration in a non-proteolytic fashion.

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Year:  2002        PMID： 12461559     DOI： 10.1038/nrm977

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  414 in total

1.  Urinary-type plasminogen activator receptor (uPAR) modulates oral cancer cell behavior with alteration in p130cas.

Authors:  Zonggao Shi; Yueying Liu; Jeffrey J Johnson; M Sharon Stack
Journal:  Mol Cell Biochem       Date:  2011-06-01       Impact factor: 3.396

2.  A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake.

Authors:  Lucy East; Afshan McCarthy; Dirk Wienke; Justin Sturge; Alan Ashworth; Clare M Isacke
Journal:  EMBO Rep       Date:  2003-07       Impact factor: 8.807

3.  Assessment of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in Breast Cancer Tissue: Historical Aspects and Future Prospects.

Authors:  Manfred Schmitt; Karin Mengele; Apostolos Gkazepis; Rudolf Napieralski; Viktor Magdolen; Ute Reuning; Nadia Harbeck
Journal:  Breast Care (Basel)       Date:  2008-10-15       Impact factor: 2.860

4.  Circulating soluble urokinase plasminogen activator receptor levels and peripheral arterial disease outcomes.

Authors:  Ayman Samman Tahhan; Salim S Hayek; Pratik Sandesara; Jamal Hajjari; Muhammad Hammadah; Wesley T O'Neal; Heval M Kelli; Ayman Alkhoder; Nima Ghasemzadeh; Yi-An Ko; Hiroshi Aida; Mohamad Mazen Gafeer; Naser Abdelhadi; Kareem Hosny Mohammed; Keyur Patel; Shipra Arya; Jochen Reiser; Viola Vaccarino; Laurence Sperling; Arshed Quyyumi
Journal:  Atherosclerosis       Date:  2017-06-08       Impact factor: 5.162

5.  Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer.

Authors:  Peter Büchler; Howard A Reber; James S Tomlinson; Oliver Hankinson; Georgis Kallifatidis; Helmut Friess; Ingrid Herr; Oscar J Hines
Journal:  Neoplasia       Date:  2009-02       Impact factor: 5.715

6.  Proteomic identification of LASP-1 down-regulation after RNAi urokinase silencing in human hepatocellular carcinoma cells.

Authors:  Alessandro Salvi; Italia Bongarzone; Francesca Miccichè; Bruna Arici; Sergio Barlati; Giuseppina De Petro
Journal:  Neoplasia       Date:  2009-02       Impact factor: 5.715

7.  Mechanisms of kringle fragment of urokinase-induced vascular smooth muscle cell migration.

Authors:  Elisa Roztocil; Suzanne M Nicholl; Mark G Davies
Journal:  J Surg Res       Date:  2007-07       Impact factor: 2.192

8.  Association between urokinase haplotypes and outcome from infection-associated acute lung injury.

Authors:  John Arcaroli; Jeff Sankoff; Nianjun Liu; David B Allison; James Maloney; Edward Abraham
Journal:  Intensive Care Med       Date:  2007-11-10       Impact factor: 17.440

9.  Urokinase-type plasminogen activator (uPA) promotes ezrin-mediated reorganization of the synaptic cytoskeleton in the ischemic brain.

Authors:  Paola Merino; Ariel Diaz; Luis Guillermo Manrique; Lihong Cheng; Manuel Yepes
Journal:  J Biol Chem       Date:  2018-05-02       Impact factor: 5.157

10.  Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2.

Authors:  Hoanh Tran; Fabienne Maurer; Yoshikuni Nagamine
Journal:  Mol Cell Biol       Date:  2003-10       Impact factor: 4.272
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