Literature DB >> 18375680

Predictive genetic testing of children for adult-onset diseases and psychological harm.

P J Malpas1.   

Abstract

One of the central arguments given to resist testing currently healthy, asymptomatic children for adult-onset diseases is that they may be psychologically harmed by the knowledge gained from such tests. In this discussion I examine two of the most serious arguments: children who are tested may face limited futures, and that testing may result in damage to the child's self esteem (where the test result returns a positive diagnosis). I claim that these arguments do not stand up to critical evaluation. In conclusion, whilst I do not suggest that all at-risk children should be tested for adult-onset diseases we ought to listen carefully to some parental requests for such testing because the putative psychological harms may not be as significant or likely as initially thought. This is because parents generally have the best interests of their children at heart and if they are properly supported and educated about predictive genetic testing and the possible consequences, then the risk of psychological harms occurring may be ameliorated.

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Year:  2008        PMID: 18375680     DOI: 10.1136/jme.2006.019802

Source DB:  PubMed          Journal:  J Med Ethics        ISSN: 0306-6800            Impact factor:   2.903


  18 in total

Review 1.  Potential Uses and Inherent Challenges of Using Genome-Scale Sequencing to Augment Current Newborn Screening.

Authors:  Jonathan S Berg; Cynthia M Powell
Journal:  Cold Spring Harb Perspect Med       Date:  2015-10-05       Impact factor: 6.915

2.  Commentary: Children and predictive genomic testing: disease prevention, research protection, and our future.

Authors:  Beth A Tarini; Kenneth P Tercyak; Benjamin S Wilfond
Journal:  J Pediatr Psychol       Date:  2011-08-04

3.  Parental attitudes toward ethical and social issues surrounding the expansion of newborn screening using new technologies.

Authors:  L E Hasegawa; K A Fergus; N Ojeda; S M Au
Journal:  Public Health Genomics       Date:  2010-07-30       Impact factor: 2.000

Review 4.  Controversies in communication of genetic screening results for cancer: a report from the American Society of Preventive Oncology's Screening Special Interest Group (ASPO's 33rd Annual Meeting, March 8 to 10, 2009, Tampa, Florida).

Authors:  Linda Patrick-Miller; Angela R Bradbury; Mary Beth Terry
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2010-02       Impact factor: 4.254

5.  Ethical issues in presymptomatic genetic testing for minors: a dilemma in Li-Fraumeni syndrome.

Authors:  Brice Fresneau; Laurence Brugières; Olivier Caron; Grégoire Moutel
Journal:  J Genet Couns       Date:  2012-12-12       Impact factor: 2.537

6.  When parents disclose BRCA1/2 test results: their communication and perceptions of offspring response.

Authors:  Angela R Bradbury; Linda Patrick-Miller; Brian L Egleston; Olufunmilayo I Olopade; Mary B Daly; Cynthia W Moore; Colleen B Sands; Helen Schmidheiser; Preethi K Kondamudi; Maia Feigon; Comfort N Ibe; Christopher K Daugherty
Journal:  Cancer       Date:  2012-01-09       Impact factor: 6.860

7.  Genetic testing of children for familial cancers: a comparative legal perspective on consent, communication of information and confidentiality.

Authors:  Roy Gilbar
Journal:  Fam Cancer       Date:  2009-07-17       Impact factor: 2.375

Review 8.  Growing up in the genomic era: implications of whole-genome sequencing for children, families, and pediatric practice.

Authors:  Christopher H Wade; Beth A Tarini; Benjamin S Wilfond
Journal:  Annu Rev Genomics Hum Genet       Date:  2013-07-15       Impact factor: 8.929

9.  Addressing the ethical challenges in genetic testing and sequencing of children.

Authors:  Ellen Wright Clayton; Laurence B McCullough; Leslie G Biesecker; Steven Joffe; Lainie Friedman Ross; Susan M Wolf
Journal:  Am J Bioeth       Date:  2014       Impact factor: 11.229

10.  Are guidelines for genetic testing of children necessary?

Authors:  Angela Fenwick
Journal:  Fam Cancer       Date:  2009-08-15       Impact factor: 2.375

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