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Literature DB >> 18340350

Low oxygen stimulates the immune system.

Abstract

Changes in tissue oxygen levels trigger molecular signaling pathways that regulate cellular proliferation and differentiation in multiple cell types. The functional role of oxygen signaling in the immune system is not well understood. Rama and colleagues demonstrate that hypoxia induces dendritic-cell maturation; thus they provide a novel mechanistic link between hypoxia/ischemia and the activation of the immune system in the kidney.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2008 PMID： 18340350 PMCID： PMC3791324 DOI： 10.1038/ki.2008.15

Source DB: PubMed Journal: Kidney Int ISSN： 0085-2538 Impact factor: 10.612

14 in total

1. HIF-1alpha is essential for myeloid cell-mediated inflammation.

Authors: Thorsten Cramer; Yuji Yamanishi; Björn E Clausen; Irmgard Förster; Rafal Pawlinski; Nigel Mackman; Volker H Haase; Rudolf Jaenisch; Maripat Corr; Victor Nizet; Gary S Firestein; Hans Peter Gerber; Napoleone Ferrara; Randall S Johnson
Journal: Cell Date: 2003-03-07 Impact factor: 41.582

Review 2. Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors.

Authors: Michail Sitkovsky; Dmitriy Lukashev
Journal: Nat Rev Immunol Date: 2005-09 Impact factor: 53.106

Review 3. Progression of kidney disease: blocking leukocyte recruitment with chemokine receptor CCR1 antagonists.

Authors: H-J Anders; V Ninichuk; D Schlöndorff
Journal: Kidney Int Date: 2006-01 Impact factor: 10.612

Review 4. Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia.

Authors: L G Fine; D Bandyopadhay; J T Norman
Journal: Kidney Int Suppl Date: 2000-04 Impact factor: 10.545

Low oxygen stimulates the immune system.

1. HIF-1alpha is essential for myeloid cell-mediated inflammation.

Review 2. Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors.

Review 3. Progression of kidney disease: blocking leukocyte recruitment with chemokine receptor CCR1 antagonists.

Review 4. Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia.

5. Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure.

6. Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction.

7. Immunohistochemical detection of hypoxia-inducible factor-1alpha in human renal allograft biopsies.

8. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

9. Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression.

Review 10. Hypoxia-inducible factors in the kidney.

Review 1. Delayed graft function in the kidney transplant.

Review 2. Smoking under hypoxic conditions: a potent environmental risk factor for inflammatory and autoimmune diseases.

Review 3. Recent Approaches to Targeting Canonical NFκB Signaling in the Early Inflammatory Response to Renal IRI.