Literature DB >> 34108233

Recent Approaches to Targeting Canonical NFκB Signaling in the Early Inflammatory Response to Renal IRI.

Shelby Reid1, James W Scholey2,3.   

Abstract

Ischemia reperfusion injury (IRI) is the most common cause of in-hospital AKI and is associated with increased morbidity and mortality. IRI is associated with an early phase of inflammation primarily regulated by the canonical NFκB signaling pathway. Despite recent advances in our understanding of the pathogenesis of IRI, few therapeutic strategies have emerged. The purpose of this manuscript is to review interventions targeting NFκB after IRI.
Copyright © 2021 by the American Society of Nephrology.

Entities:  

Keywords:  NF kappaB; inflammation; ischemia-reperfusion

Mesh：

Substances：

Year:  2021        PMID： 34108233      PMCID： PMC8729839          DOI： 10.1681/ASN.2021010069

Source DB:  PubMed          Journal:  J Am Soc Nephrol        ISSN： 1046-6673            Impact factor:   14.978


  102 in total

1.  Inhibition of BRD4 attenuates transverse aortic constriction- and TGF-β-induced endothelial-mesenchymal transition and cardiac fibrosis.

Authors:  Shuai Song; Liang Liu; Yi Yu; Rui Zhang; Yigang Li; Wei Cao; Ying Xiao; Guojian Fang; Zhen Li; Xuelian Wang; Qi Wang; Xin Zhao; Long Chen; Yuepeng Wang; Qunshan Wang
Journal:  J Mol Cell Cardiol       Date:  2018-12-07       Impact factor: 5.000

2.  Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK.

Authors:  Rudolf Waelchli; Birgit Bollbuck; Christian Bruns; Thomas Buhl; Jörg Eder; Roland Feifel; Rene Hersperger; Philipp Janser; Laszlo Revesz; Hans-Günter Zerwes; Achim Schlapbach
Journal:  Bioorg Med Chem Lett       Date:  2005-10-19       Impact factor: 2.823

3.  Testosterone is responsible for enhanced susceptibility of males to ischemic renal injury.

Authors:  Kwon Moo Park; Jee In Kim; Youngkeun Ahn; Andrew J Bonventre; Joseph V Bonventre
Journal:  J Biol Chem       Date:  2004-09-08       Impact factor: 5.157

4.  Interleukin-1 receptor-associated kinase (IRAK) -1-mediated NF-kappaB activation requires cytosolic and nuclear activity.

Authors:  Gang Liu; Young-Jun Park; Edward Abraham
Journal:  FASEB J       Date:  2008-02-14       Impact factor: 5.191

5.  Melatonin attenuates unilateral ureteral obstruction-induced renal injury by reducing oxidative stress, iNOS, MAPK, and NF-kB expression.

Authors:  Emin Ozbek; Yusuf Ozlem Ilbey; Mustafa Ozbek; Abdulmuttalip Simsek; Mustafa Cekmen; Adnan Somay
Journal:  J Endourol       Date:  2009-07       Impact factor: 2.942

6.  Major effects of delayed graft function and cold ischaemia time on renal allograft survival.

Authors:  Isabel Quiroga; Philip McShane; Dicken D H Koo; Derek Gray; Peter J Friend; Susan Fuggle; Christopher Darby
Journal:  Nephrol Dial Transplant       Date:  2006-02-20       Impact factor: 5.992

Review 7.  New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract.

Authors:  Geneviève Coulombe; Nathalie Rivard
Journal:  Cell Mol Gastroenterol Hepatol       Date:  2015-11-14

8.  Lentivirus-Mediated Silencing of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 Inhibits Release of Inflammatory Cytokines and Apoptosis in Renal Tubular Epithelial Cells Via Inhibition of the TLR4/NF-kB Pathway in Renal Ischemia-Reperfusion Injury.

Authors:  Jing-Fei Teng; Kai Wang; Zhuo-Min Jia; Yan-Jie Guo; Ya-Wei Guan; Zhi-Hui Li; Xing Ai
Journal:  Kidney Blood Press Res       Date:  2018-07-10       Impact factor: 2.687

Review 9.  HMGB1: endogenous danger signaling.

Authors:  John R Klune; Rajeev Dhupar; Jon Cardinal; Timothy R Billiar; Allan Tsung
Journal:  Mol Med       Date:  2008 Jul-Aug       Impact factor: 6.354

10.  Podocyte NF-κB is dispensable for the pathogenesis of renal ischemia-reperfusion injury.

Authors:  Maho Yamashita; Tadashi Yoshida; Matsuhiko Hayashi
Journal:  Physiol Rep       Date:  2016-08
View more
  8 in total

1.  The cell membrane repair protein MG53 modulates transcription factor NF-κB signaling to control kidney fibrosis.

Authors:  Haichang Li; Pu Duann; Zhongguang Li; Xinyu Zhou; Jianjie Ma; Brad H Rovin; Pei-Hui Lin
Journal:  Kidney Int       Date:  2021-10-30       Impact factor: 10.612

2.  Exosomal lncRNA TUG1 derived from human urine-derived stem cells attenuates renal ischemia/reperfusion injury by interacting with SRSF1 to regulate ASCL4-mediated ferroptosis.

Authors:  Zejia Sun; Jiyue Wu; Qing Bi; Wei Wang
Journal:  Stem Cell Res Ther       Date:  2022-07-15       Impact factor: 8.079

3.  Estradiol Ameliorates Acute Kidney Ischemia-Reperfusion Injury by Inhibiting the TGF-βRI-SMAD Pathway.

Authors:  Lian Ren; Fang Li; Ziyang Di; Yan Xiong; Shichen Zhang; Qing Ma; Xiaoen Bian; Zhiquan Lang; Qifa Ye; Yanfeng Wang
Journal:  Front Immunol       Date:  2022-02-24       Impact factor: 7.561

4.  Ischemia-Reperfusion Injury and Immunosuppressants Promote Polyomavirus Replication Through Common Molecular Mechanisms.

Authors:  Xu-Tao Chen; Yang Huang; Jing Wang; Ge Li; Yu Zhang; Li-Fang He; Yue-Xiao Lian; Shi-Cong Yang; Guo-Dong Zhao; Hui Zhang; Jiang Qiu; Lei Zhang; Gang Huang
Journal:  Front Immunol       Date:  2022-02-25       Impact factor: 7.561

5.  Co-treatment with Esculin and erythropoietin protects against renal ischemia-reperfusion injury via P2X7 receptor inhibition and PI3K/Akt activation.

Authors:  Walaa H El-Maadawy; Marwa Hassan; Ehab Hafiz; Mohamed H Badawy; Samir Eldahshan; AbdulRahman AbuSeada; Maha A M El-Shazly; Mosad A Ghareeb
Journal:  Sci Rep       Date:  2022-04-14       Impact factor: 4.996

6.  Dexmedetomidine Attenuates Ferroptosis-Mediated Renal Ischemia/Reperfusion Injury and Inflammation by Inhibiting ACSL4 via α2-AR.

Authors:  Wen-Hui Tao; Xi-Sheng Shan; Jia-Xin Zhang; Hua-Yue Liu; Bi-Ying Wang; Xiang Wei; Mian Zhang; Ke Peng; Jun Ding; Shang-Xian Xu; Lin-Gui Li; Jun-Kai Hu; Xiao-Wen Meng; Fu-Hai Ji
Journal:  Front Pharmacol       Date:  2022-06-14       Impact factor: 5.988

7.  Tubular IKKβ Deletion Alleviates Acute Ischemic Kidney Injury and Facilitates Tissue Regeneration.

Authors:  Eileen Dahlke; Toni Engmann; Yaman Anan; Robert Häsler; Giovanni Solinas; Franziska Theilig
Journal:  Int J Mol Sci       Date:  2022-09-05       Impact factor: 6.208

8.  Itaconic acid facilitates inflammation abatement and alleviates liver ischemia-reperfusion injury by inhibiting NF-κB/NLRP3/caspase-1 inflammasome axis.

Authors:  Ensi Ma; Hao Xing; Jiahao Pei; Quanbao Zhang; Ruidong Li; Conghuan Shen; Yifeng Tao; Jianhua Li; Zhenyu Ma; Jing Zhao; Zhengxin Wang
Journal:  Ann Transl Med       Date:  2022-08
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.