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Literature DB >> 18338857

Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence.

Julica Nöth¹, Kevin J Frankowski, Benjamin Neuenswander, Jeffrey Aubé, Oliver Reiser.

Abstract

A three-component method for the synthesis of highly substituted gamma-lactams from readily available maleimides, aldehydes, and amines is described. A new reductive amination/intramolecular lactamization sequence provides a straightforward route to the lactam products in a single manipulation. The general utility of this method is demonstrated by the parallel synthesis of a gamma-lactam library.

Entities: Chemical

Mesh：

Substances：

Year: 2008 PMID： 18338857 PMCID： PMC2713763 DOI： 10.1021/cc700202c

Source DB: PubMed Journal: J Comb Chem ISSN： 1520-4766

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